עבודת סיום וירולוגיה

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    15-Aug-2014

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a summary of viruses and treatments for viral infections - in hebrew

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<p>Herpes Viruses: dsDNA. +( spikes ). . . . " ' . ( ' )HIV , , (, , UV') -, . :,, o , (, ,CNS ). 1( HSV ), 2( HSV ) -( VZV + ). o (7-3 ), ' - . .CMV - o , B. EBV , 5 -, . 5 HHV . )HSV (Herpes Simplex Virus , ( / - ). . 2 HSV " 1 .HSV primorg recurrent labialis . . , . DNA , 2 .tegument (002 .)Kb- spikes . ( ) -.nuclear pores )-TIF (trans inducing factor . )VHS (virion host shutoff mRNA " mRNA. HSV ,, immediate earlyo -TIF TF. TF '. earlyo DNA pol, TF ' '. lateo '. - DNA - .rolling circle . , scaffold . , . -DNA .</p> <p> . ( ). mRNA . . , , ( ). - S . ( ). ( ) -.spikes , , TF , - -TIF . LAT (latency .)associated transcript .)UL, US (long, short LAT ICPO ( .) - mRNA - - LAT . - LAT "" (, -). LAT - . - ,UV TF . , . : ' . 2- HSV , . , . ' . %51, . ( 1). ' . (= ) . ' , ( ) ' . acyclovir - .CNS . Acyclovir ,DNA . . , . , DNA pol - DNA, ( ). , .,,lat DNA -. DNA - , . () . )Varicella Zoster Virus (VZV . . . .</p> <p> - ,HSV , " ". - DNA .HSV - ,HSV , ( , , -01 02 ). , ( ). , . ' " . 2/1- HSV- VZV " . - VZV . - HSV .VZV - VZV -( HSV , ). " . : o . o . .I o ' " .II , . " -01 . . ' ' . . . -21 ' : o . o . . o ' . o . , , - VZV . ( VZV) , . , - ,HSV ' . ( , ) -. RNA, . , - " . - . ' . ( - booster). ( ) -. - ( ' ). - . , "" , . , . . - (-). " - . " . - ( ). ", .</p> <p> Ramsey-hunt syndrome - zoster . , (), , , . , " .VZV Bell's palsy " 1- HSV , , 7. - " . ' %89 . . ' . ( 3 ) : 1.. 2. VZIP /. 3. VZIG ". (1 , 3 ). HCMV- Human Cytomegalo Virus , (042 .)kbp . - , (01-7 ). . , . " PCR " . . ( ). . , " . " . CMV mononucleosis : , , , , (), (), . (, , , , , ,CSF, , ). ( ). . (= ). . ". -, . - . ( " , ' ). . . - ( ) . . -, %2.0 - CNS. , -. -%08-06 CV. %2.2 - - %2.0 - CNS. : . -:CMV o, o . . o o o . o o . o " PCR , , . , -</p> <p> CMV . " ( )Avidity ( = ). , . , . - gancyclovir . - foscarnet - DNA ( ). ( ) . ' : " 1- MHC- ER" .3US 2 US-11 US . 6 US . - immediate early protein CTL . 2 US 2- MHC 441 CD4. UL -04 TNF. UL .NK EBV Epstein Barr Virus ( , .)B -infectious mononucleosis , nasopharyngeal carcinoma , Burkitt's .lymphoma - .S DNA . '' , . , ( )restricted , ' . RNA, EBV .RNA B , . ' , , ' , . - B" , , . , - EBV , . EBV ' ( B" C3d ' ). - B . B , . . . " , " ' 6-501/1, . : - EBNA LMP T. - ". . - . . Burkitt's Lymphoma , " . - B . </p> <p> ( ) , . - . -Nasophayngeal Carcinoma , , - . Infectious Mononucleosis , " , . , ,B " " ' , , . , . . " -. . 05-03 , . -01 , 4-2 ( - ). Oral Hairy Leukoplakia , / . .</p> <p> : 1) (-, ') 2): . ' . . 3) (" , ) 4) ( )HSV, HIV, HPV 5) ( ) ' . : " . DNA ,RNA ( )ds (.)ss . RNA ( )+RNA - ,mRNA ( )-RNA antisense- RNA . " , , . : 1) Acute , Rhinovirus, Rotavirus 2) Persistent , Lymphocytic choriomeningitis Virus 3) Latent , , .HSV 4) Slow HIV .Measles SSPE : 1) DNA- ,RNA .. 2) . 3) , . 4) . 5) , . 6) , . . : 1) ( ) 2) 3) (.)uncoating 4) mRNA 5) 6) 7) mRNA 8) " .</p> <p> : 1), 2)pH 3) UV 4) , , , .HCl , '. ": 1) " ,PFU, FFU 05.LD50, TCID 2) ' " OD - .EM</p> <p> : 1) . (, ), (, ,)CSF , (, , ) . ( )CPE" , " . " ,ELISA (, PCR, LCR' ). 2) " , , , ( ). False Positive " RF . . -.CSF</p> <p> 15 , 5 , C-G. dsDNA -042 , . , . ( , " ).</p> <p> , . . , . . ,inclusion bodies . , . 4 " , 601/1- 01/1. . ' (. ), ( ), ' . / ( , ). . ( -) " 6,5,2,1 , ' . ' . 04 -14 -.GI 4 -7 - acute respiratory distress . . " . . 5 pentone base .fiber mRNA . , . , . , , . - fiber knob " , . -receptor mediated endocytosis . , DNA ( ) . Early events . , . - early . immediate early a " . Immediate early b . - mRNA ( )TF .S ' ( ). DNA-pol ( - mRNA -RNA-pol ). , " - RB-35 p . - mRNA .</p> <p> RNA vaRNA - . Replication &amp; Late events , - .Late mRNA . leading- .lagging . . terminal protein - DNA . . . . - early - .late mRNA dsRNA " -. - " ( E1 - TF -INF ) -( vaRNA dsRNA PKR. INF -dsRNA . PFU .INF - vaRNA PFU INF .INF 3 E " CTL-.TNF E1A - early pRB -.S E1B 35 p . - early - late , .</p> <p> RNA RNA RNA+ (RNA , )mRNA -RNA (RNA , -RNA ). RNA ( )Ambisense +RNA ,-RNA - RNA - DNA - .mRNA RNA " . " . " - - mRNA . -RNA , -.Influenze A "(+) - picornaviridae " -. . - - -, -, -. . : "(+) .ss ( ). 5' VPg 3' poly-A " . VPg - ,poly-A 3'. -</p> <p> VPg - polyprotein . " . , . " leading sequence , "" . , " " IRES (intra-ribosomal )entry site . salk - sabin ( ). ( ) , - sindbis -.togaviridae "(-) VSV-vesicular stomatitis virus " " " . 84 . " . '3 . , " " . " N " . N " . Orthomyxoviruses (" " " , ). ( )reassortment ' . - . ( )S, L " , S " . .MMLV, HIV, HTLV MMLV " , ,ss direct repeats- UTR '3 -'5. ( RT " ") ( " ). tRNA - .RT , . ". " ( , ) . "" . ( HIV) - .S " "" .</p> <p> DNA</p> <p> " - -, " , . . ( .)Pox , " " . , origin, . " ,ds " " IE " . " . , . " ,ss . " . , 04- :SV " - . " )TAG (T antigen . " . . , . 3 ( ) . , . " " , " , .S . . , - ,S . Rb .S 35 p . BAX .</p> <p> Picorna " (42-81 .)nm -4 - : o ( - pH ' , -.)GI , , . o- o o- ( ' , ' ' ). : " (+) 007 . ( ).</p> <p>-: . (), (), ( ,)A ( A), ( ,)B ( ,B). " - . ' ' . . - ,A A B . : 3 , . . -, %8-5 , , , , , . . %2-1 CNS . - . , ( ) . - ,BBB () . salk IV . Sabin PO , ( .)IgA .</p> <p> , , , . 3 1) 2) 3) . ' " (, ,)HIV () ' . " , " ' . ' - IFN " " - (" - ). IFN - NFB . - .IFN IFN 5-2 (A)-synthetase DNA ADAR " , ", ". , HSV " - ADAR- HIV " .ADAR ' - TNF . - TNF - TNF . 3 TNF . , TNF , NFB " . (" ) . " " - TNF </p> <p> -</p> <p> . ( - Pox) - TNF " , -, TNF . " " ( ). ' - :PKR " IFN .dsRNA -PKR . ( ,EBV, ,HIV) ' dsRNA - PKR , -PKR , . " " , ' . RNA " , -.mRNA " ". , . -" ( )siRNA . , . , .</p> <p> " ,paramyxoviridae . . , 41-01 . " -, -01 . %59 . , 3-2 , , , ', , . -01 . koplik ,spots . ( ,enanthema ), ( .)exanthema . - - . - , , , , ( ) ( -). - . : ( ), ' , ( ), , ( .subacute sclerosing pan-encephalitis) SSPE , , , , . ( .)MMR , - .</p> <p> - Measles</p> <p> Mumps , " paramyxoviridae (81 ), . , ( -). -6 .</p> <p> , -, , ( ), / ( ) .</p> <p> )+(RNA ,togaviridae , . ( ). (3-2 ). -. , , -, /. , " ,CPE . . , , , ( ) . . , , . " , , , ( ) - . " ( ), " . reoviridae dsRNA -11 . , . . 3 A,B,C . , , " -01 . . - . . .</p> <p> -Rubella</p> <p>Rotavirus</p> <p>(human papiloma virus) HPV papovaviridae 37 (" "). " - HPV " -, . . ( , ) 000,01 " . , . . : o - , o - ,laringial papiloma ( ), oral papiloma-.conjuctival papiloma</p> <p>o -' - , . " 61, 81 -13 " " , .UV )CR (conserved regions Rb . ": - pap-smear ; papanicolao " " " .PCR , , INF- .</p> <p>Orthomyxoviridae .influenza A,B,C A- B . )-(ssRNA -8 ( )HA ( )NA . " . -pH . " - mRNA. , . , , , . . ( , ), ( ), . . . " : Antigenic drifto . NA HA . Antigenic shifto , NA- HA . , . - pH ( ,)A ( NA ). " " A .B , , , 05 '. 3 , RSV- .parainfluenza )-(ssRNA ( HN+), F . " . " . - Parainfluenza - .croup" , . RSV , . . . . .</p> <p>Paramyxoviridae</p> <p> Metapneumovirus , , . . - .SARS )+(ssRNA . -01 , , . . - SARS " , . , . . . .</p> <p>Coronaviridae</p> <p> . () , , , , (,ALT, AST ,)AKP ( 2/1 T ) %26( ,)A %72( )B C-G. HEV . HAV ,picornaviridae " , ( ). -, . 5, - %59 -. -%57 . , ( ,IgM" .)IgG . . . HBV Hepadnaviridae . ( dsDNA , ). . . , . , . -%09 . 081-54 . %01 " . ( ) . " , . , . , -, , 5 . ,S , . - DNA . ( ) ' "" . " , . , . .</p> <p> HDV HBV . " " .HBV " HBV . - HDV HBV . - HBV- HDV . HCV " ,flaviviridae , . , %57 " . ' . ,B . 02-01 . ' , . " . HEV , %51 - HAV-.)HBV (NANB ( HAV , ). -04 . -%2, . " .PCR . . . , , , . , , , . " , , . , . , , ,poxviridae-1- .HSV . . ( ,)cDNA . " , . . " . . . , , ' . , , , . ( ) . - : o (35 )Rb, P , . BAX 2 BCL .</p> <p>Gene Therapy</p> <p>o ( ) . , . o . ( )SCID . ' , ,T . " RT , , .</p> <p> - " " " : . ,ssRNA . ( - )flaviviridae " . " " . -4 : Arenaviridaeo - ,EM Bunyaviridaeo ,Rift valley fever , . Filoviridaeo . Flaviviridaeo , , . " , . . -6791. , . . ,)-(ssRNA , ( " ). 12-2 , , , , , . , - -. , . , . ", ( ) , . . , . , , . Arenavirus : . ssRNA .ambisense " " . . ' , . -01 , . -%51 , . Dengue Fever " 4 .flavivirus , , </p> <p>Hemorrhagic fever viruses</p> <p> . " ( ). ' , , , . ( ) -. " . " (" " , yellow fever " ). ', - BBB . -virus togaviridae " . -.equine encephalitis Flavivirus .picorna , , . ( )Rabies ' . , , . . -%001 " , . ( ) ' . " , ' . " . CPE . . , , ( ) . - )-(ssRNA " . - ,picorna ( HSV- VZV). HTLV , . Progressive Multifocal Leukoencephalopathy " JC ". . .dsDNA " ( ) . Smallpox , . , - %05 . dsDNA " -3 . 4-2 ( .)prodrome ' . ( ), . (). , . 4 : V.majoro </p> <p>Poxviridae</p> <p> V.minoro . Flato " ,...</p>