Сиволоб_Молекулярная биология

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<p>. . </p> <p> 577.2(075.8) 28.07073 34: - . , ., . . . ( ); - . , ., .-. . . ( ); - . , ., .-. . . ( .. )</p> <p> 5 2007 </p> <p>, .. 34 : / .. . . : , 2008. 384 . ISBN 978-966-439-068-9 . , . , , , , . , . , , , . . 248. .: 159. ( 1.4/18-.-1431 27.08.07)</p> <p> 577.2(075.8) 28.07073</p> <p>ISBN 978-966-439-068-9</p> <p> .. , 2008 , , 2008</p> <p> ............................................................................................8 ....................................................................................................9 1. - .......................13 ....................13 .................................................................13 .......16 ' .......................19 ' ...................................19 .......................20 ' .........................................................22 ................23 ..............................................23 () ...................................25 ' ............................................................27 .......................................................29 2. ...................................................................................33 ................................................................33 ..................................................................33 ' ...................35 .................................................................37 - .........................................................................37 - ....................................................................39 310 ......................................................................40 -........................................................................40 ...............................................................40 ...............41 ........................................................42 .................44 .........................................50 ....................................................51 .............................................51 ............................................53 ..............................54 ..............57 3. .....................................................................................65 ..........................................65 .....................................................................65</p> <p> ..............................................68 .........................................................................69 .......................................................................70 .........................................70 .................74 ..................................................76 - .......................................................78 - .....................................................81 , ...................................................81 - ....................88 .......................................................................93 4. : .................................................................... 103 ................................................................ 103 ............................................................. 103 ............................................................................... 105 ........................................................................... 106 ...................................... 115 ................................................................... 115 ....... 121 1 ....................................................................... 124 ....... 125 ......... 127 5. : ................................................ 131 - ....................................................................... 131 ............... 131 - ........................................... 133 ............................................................ 136 .......................................................... 139 ......................................................... 145 ........................................................... 147 ......................................................... 147 ............................................................. 149 ..................................................................... 150 ........................ 152 . 156 6. : ................................................... 159 - II.................................................................... 160 - ........................................ 160 - ......................................... 1624</p> <p> .................................... 163 - .................. 167 - .............................................................. 168 ............... 168 - ................. 169 ......................................... 170 .............................................. 171 .......................................... 173 ................................................. 176 ................................................ 177 ......................... 178 HMG ................... 183 - ............................ 186 : ........ 189 .............................................. 189 1- ...................................... 191 ........................................................ 193 - ....................................................... 194 7. ....................................... 201 ............................................................................... 201 ............................................................................... 204 : .............................. 205 ................ 209 ..................................................... 212 - ..................................................................... 215 .................................................................. 217 8. ..................................................................... 221 ..................................................................... 221 ............................................................ 221 ................................................ 225 ................................................................................. 230 ............................................................ 230 ..................................................... 231 ................................................................. 239 EF1 ............................................ 240 ' - - .................. 242 ........................................................... 247 ................................................................. 249 ................................................................. 253 ................................. 2545</p> <p> ................................... 256 ............................................................. 258 ................................................................ 259 .............................. 262 ................. 263 hsp70 ........................................................... 267 ................................................................... 270 9. ................................................................. 275 .................................................................................. 276 - ...................................................................... 279 - ...... 279 .................................................... 282 - - ....................................................... 283 ...................... 284 SSB ..................................................... 284 , ................................ 286 - ...................................... 288 , ' ............. 290 ................................................ 292 ....................... 293 - ...................................... 294 .................................... 295 ........... 296 .............. 298 ........................................................................ 300 ........................................................... 300 ................................................... 301 ................................................... 303 ................................................ 304 .............................. 306 10. ........................................................... 309 ....................................................... 310 - .............................................. 316 ......................................................... 318 V(D)J- .......................... 319 .......................................... 323 -.......................................................... 323 LTR-........................................................... 324 LINE SINE ................................... 3256</p> <p> 11. .......................................... 331 , ..................... 331 ........................................................... 331 -......................................................... 335 ................... 337 ................................... 339 ....................................................... 341 ............................................................ 343 ............................................ 344 ............. 347 - ......................................................... 347 ........................................... 349 ................................................. 351 - ........................ 353 - - ..... 353 ................................................................. 354 ...................................... 355 ................................................ 356 ................................................ 358 ...................... 358 ......................................... 360 ......... 361 ............ 365 ................................................... 369 ..................................................................... 377</p> <p>7</p> <p> . . . , ' , , , , . , . ( ), , , . , , . : , , , . . , . , , , , , , , . .. , .. .. , . .. </p> <p>, , , , . , : </p> <p> . , , . , , . ' : . - , . : , , - . , . , . ( ) , 20 . . </p> <p> .. </p> <p> ( , ). , , . , - : , , , . 2. : , , , (). , , ( , ) (). , . , . , , , . , . , , 3. , , , . , , . , , , ( ) . 4 , - , . 10</p> <p> , . , , . , , . , ( ) . , -. , , ( ). - 5 6. ' ( - ) 7. 8 . , . : (), . ' . , (), ' . ( ) . 8. () , . . : -.11</p> <p> .. </p> <p> . , , , ' , ' . 9. 10 , . 11 , . . . , , . , , (PDB Protein Data Bank, http://www.rcsb.org/pdb/, PDB ) PyMOL (http://www.pymol.org/) UCSF Chimera (http://www.cgl.ucsf.edu/chimera). , ., , ., , . . : 3 . . : , 1993. ., . : 2 . . : , 1998. Lewin, B. Genes VIII. Upper Saddle River. New Jersy : Pearson Prentice Hall, 2004. Lodish, H., Berk, A., Zipursky, L.S. et al. Molecular cell biology. New York : W.H. Freeman and Company, 2000. Weaver, R.F. Molecular biology. New York : McGraw-Hill Companies, 2002.</p> <p>12</p> <p> 1 - All science is either physics or stamp collection. E. Rutherford</p> <p> , , . , . , .</p> <p> : , . 1.1, ' . . . , . . 1.1 1 ( W1 ). 2 () W2 . f2 2 f1</p> <p> .. </p> <p> 1 ( K 2 1), , :</p> <p>K=</p> <p>f 2 W2 . = f1 W1</p> <p> W2 </p>