Диффузная передача сигнала

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<ul><li><p> 4</p></li><li><p> - </p><p> -- - (, )</p><p> , </p><p> , </p></li><li><p> 4.1</p></li><li><p> ( mGluR, ) ( , NMDA, )</p><p> ( , NMDA ) </p></li><li><p> ( ) NMDA AMPA , </p></li><li><p> (spill , over : ) </p></li><li><p> Po,max cleft - D NMDA , AMPA </p></li><li><p> () (b) () </p></li><li><p> NMDA () : , NMDA </p></li><li><p> . , .600 nm</p></li><li><p> LTP (A) NMDA, AMPA . LTP AMPA . (B) () , NMDA ( AMPA) . - , LTP .</p></li><li><p>- , , - , </p></li><li><p> 4.2</p></li><li><p> ( )</p><p> ( ) </p></li><li><p> - ( ) () </p></li><li><p> ? !300 </p></li><li><p>, </p></li><li><p> : = / </p></li><li><p> ( ) </p><p> Na+ K+ () Na+ Cl- (, , , , )</p><p> () () </p></li><li><p> , . . , , , 2005 </p></li><li><p> ( ) ( ) .</p><p> kon koff: , .</p><p> , 2005</p></li><li><p> () </p></li><li><p> 4.3</p></li><li><p> Ca2+ Ca2+ , </p></li><li><p> Ca2+, Ca2+ 2+</p></li><li><p> 4.4</p></li><li><p> (a) . (b) , . .(c) . .</p></li><li><p> CA 1CA 3DG+ in vivo</p><p>+ (, , )</p><p>+ </p><p>+ ( )</p></li><li><p> 1. 2. 150 mM [Cl-]oIR-DIC image</p></li><li><p>D-APV (50 M) NMDA </p><p>NBQX (25 M) AMPA/ </p><p>CGP52432 (5 M) B </p></li><li><p> Semyanov et al. Nature Neurosci. 2003 </p></li><li><p> Semyanov et al. Nature Neurosci. 2003 </p></li><li><p> , :</p></li><li><p> Semyanov et al. Nature Neurosci. 2003 ++ , </p></li><li><p> .</p></li><li><p> : </p><p>5- (5-DHP)</p><p>3,5- (3,5-THP; ) </p><p>3,5-THP .</p><p> (THDOC) , .</p></li><li><p> THDOC , </p></li><li><p> , </p><p>Diffuse signalling together with intracellular reactions determines the state of neuronal membrane (e.g conductance, signal to noise ratio of neuronal firing pattern, phase portrait of firing pattern, integration time window, input-output function etc).</p></li></ul>

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