А Н Т И Н Е О П Л А С Т И Ч Н И И И М У Н О М О Д У Л И Р А Щ И L

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<ul><li><p> L L 01</p><p> : ; ; - ( )</p></li><li><p> DNA : - () ; , , , .</p></li><li><p>DNA - </p></li><li><p> DNA ( ).</p><p> , . DNA .</p></li><li><p> DNC : (Actinomycin D),Chloroquine () . ( ).3. (Bleomycin).</p></li><li><p>: -, , .</p><p> DNC, N7 . : .1. --</p></li><li><p> N, S, O-, , . . , - , .</p></li><li><p>19 . S- . S- , .N- - -. </p></li><li><p> , 1942 . - .</p></li><li><p> - .</p></li><li><p> N- (Chlorambucil) .</p></li><li><p>Melphalan (Sarcolysine)4-[(2-)]-L-</p><p> 2007 4-bis(2-chloroethyl)amino-L-phenylalanine</p></li><li><p>Chlorambucil4-[(2-)] </p><p>Ph Eur 4,4-[di(2-chloroethyl)amino]phenylbutyric acid</p></li><li><p>2. Busulfan1,4- (1,4-())</p><p>Ph Eur butane-1,4-diyl di(methanesulphonate) . </p></li><li><p> .</p></li><li><p>3. 1,6-Dibromo-1,6-dideoxy-D-mannitol 8, , .</p></li><li><p>4. - (), .</p></li><li><p>N-(2-)-N--N-</p><p>N,N-(2-)- N-Ph Eur 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoureaPh Eur 1,3-bis(2-chloroethyl)-1-nitrosourea</p></li><li><p> Lomustine</p></li><li><p> N- ,</p><p> , Carmustine , , , 2-, .</p></li><li><p>CARMUSTINE2- </p></li><li><p>--</p><p>N,N- Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide monohydrate; 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine-2-oxide monohydrate;</p><p>Ph Eur (2RS)-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide</p></li><li><p> , .Cyclophosphamide, , . . , .: rodrugs .</p></li><li><p> Cyclophosphamide: oxazaphosphorinesN,N-(2-)</p></li><li><p>4- - </p></li><li><p>5. .N- (1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide 1963 . 7, , , Mg, S, .</p></li><li><p> - 4--N-</p></li><li><p> 5-(3,3-Dimethyl-1-triazenyl)-1 H- imidazole-4-carboxamide </p><p> 2007 5-(3,3-dimethyltriazeno)imidazole-4-carboxamid</p></li><li><p>DACARBAZINE</p><p>5---4- - </p></li><li><p>1940 . . . . , () , .</p></li><li><p> , , . : 100 000 - METHOTREXATE, Folic acid.</p></li><li><p>1940 . FOLIC ACID</p><p>METHOTREXATE</p><p>N- [4-[[(2,4--6-)]-]]-L- Ph Eur (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid</p></li><li><p> Methotrexate</p></li><li><p>N-(4-)-L- </p></li><li><p>Azathioprine 6-[(1--4--1--5)]-1-Ph Eur 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine</p></li><li><p>Thioguanine 2--1,7--6--6-(2--6-)</p></li><li><p>MercaptopurinePh Eur 7H-purine-6-thiol</p></li><li><p>Fluorouracil 5--2,4(1,3)-Tegafur 5--1-(-2-)-2,4(1,3)-Ph Eur 5-fluoropyrimidine-2,4(1H,3H)-dione</p></li><li><p> , ( DN). DN .</p></li><li><p>DACTINOMYCIN 1940 .: Actinomycins : </p><p>Streptomyces parvullus</p></li><li><p>DAUNORUBICIN 1963 .() Streptomyces peucetius</p><p>Streptomyces coeruleorubidus</p></li><li><p>Daunorubicin Hydrochloride(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloridePh Eur </p></li><li><p>DOXORUBICIN</p><p>Streptomyces peucetius14--</p><p>Doxorubicin HydrochloridePh Eur Streptomyces coeruleorubidus(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride</p></li><li><p>EPIRUBICINE4- DoxorubicinEpirubicin HydrochloridePh Eur (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride</p></li><li><p>BLEOMYCINS</p><p>Streptomyces verticillusBleomycin SulphatePh Eur ~ 65%~ 20-30%</p></li><li><p> PODOPHYLLOTOXIN , -.</p><p>Podophyllum peltatum</p><p>: , .</p><p> - -</p></li><li><p>Podophyllotoxin . </p><p>Ph Eur (5R,5aR,8aR,9S)-9-[[4,6-O-[(R)-thylidene]-b-D-glucopyranosyl]oxy]-5-(4-hydroxy-3, 5-dimethoxyphenyl)-5,8,8a,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-6(5aH)-one- </p></li><li><p>Podophyllotoxin . </p></li><li><p>Vinca alkaloidsVinca rosea CATHARANTHINE</p></li><li><p>Vinblastine Sulphate Ph Eur </p></li><li><p>Vincristine SulphatePh Eur</p></li><li><p>(TAXOL)TAXUS BREVIFOLIA, TAXACEAE</p><p>Paclitaxel 1960 . 1970 . 1994 .</p></li><li><p> , - ( )</p><p> Prodrug drug.</p><p> 2007 Fosfestrol Sodiumtetrasodium (E)-4,4-(1,2-diethylvinylene)bis (phenyl orthophosphate)</p></li><li><p> 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate,Tamoxifen CitratePh Eur </p></li><li><p> Ph Eur (3RS)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione</p></li><li><p>Triptorelin Luteinizing hormone-releasing factor</p></li><li><p> Ph Eur cis-diamminedi-chloroplatinum (II)</p></li></ul>

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