А Н Т И Н Е О П Л А С Т И Ч Н И И И М У Н О М О Д У Л И Р А Щ И L

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  • L L 01

    : ; ; - ( )

  • DNA : - () ; , , , .

  • DNA -

  • DNA ( ).

    , . DNA .

  • DNC : (Actinomycin D),Chloroquine () . ( ).3. (Bleomycin).

  • : -, , .

    DNC, N7 . : .1. --

  • N, S, O-, , . . , - , .

  • 19 . S- . S- , .N- - -.

  • , 1942 . - .

  • - .

  • N- (Chlorambucil) .

  • Melphalan (Sarcolysine)4-[(2-)]-L-

    2007 4-bis(2-chloroethyl)amino-L-phenylalanine

  • Chlorambucil4-[(2-)]

    Ph Eur 4,4-[di(2-chloroethyl)amino]phenylbutyric acid

  • 2. Busulfan1,4- (1,4-())

    Ph Eur butane-1,4-diyl di(methanesulphonate) .

  • .

  • 3. 1,6-Dibromo-1,6-dideoxy-D-mannitol 8, , .

  • 4. - (), .

  • N-(2-)-N--N-

    N,N-(2-)- N-Ph Eur 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoureaPh Eur 1,3-bis(2-chloroethyl)-1-nitrosourea

  • Lomustine

  • N- ,

    , Carmustine , , , 2-, .

  • CARMUSTINE2-

  • --

    N,N- Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide monohydrate; 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine-2-oxide monohydrate;

    Ph Eur (2RS)-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

  • , .Cyclophosphamide, , . . , .: rodrugs .

  • Cyclophosphamide: oxazaphosphorinesN,N-(2-)

  • 4- -

  • 5. .N- (1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide 1963 . 7, , , Mg, S, .

  • - 4--N-

  • 5-(3,3-Dimethyl-1-triazenyl)-1 H- imidazole-4-carboxamide

    2007 5-(3,3-dimethyltriazeno)imidazole-4-carboxamid

  • DACARBAZINE

    5---4- -

  • 1940 . . . . , () , .

  • , , . : 100 000 - METHOTREXATE, Folic acid.

  • 1940 . FOLIC ACID

    METHOTREXATE

    N- [4-[[(2,4--6-)]-]]-L- Ph Eur (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid

  • Methotrexate

  • N-(4-)-L-

  • Azathioprine 6-[(1--4--1--5)]-1-Ph Eur 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine

  • Thioguanine 2--1,7--6--6-(2--6-)

  • MercaptopurinePh Eur 7H-purine-6-thiol

  • Fluorouracil 5--2,4(1,3)-Tegafur 5--1-(-2-)-2,4(1,3)-Ph Eur 5-fluoropyrimidine-2,4(1H,3H)-dione

  • , ( DN). DN .

  • DACTINOMYCIN 1940 .: Actinomycins :

    Streptomyces parvullus

  • DAUNORUBICIN 1963 .() Streptomyces peucetius

    Streptomyces coeruleorubidus

  • Daunorubicin Hydrochloride(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloridePh Eur

  • DOXORUBICIN

    Streptomyces peucetius14--

    Doxorubicin HydrochloridePh Eur Streptomyces coeruleorubidus(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

  • EPIRUBICINE4- DoxorubicinEpirubicin HydrochloridePh Eur (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

  • BLEOMYCINS

    Streptomyces verticillusBleomycin SulphatePh Eur ~ 65%~ 20-30%

  • PODOPHYLLOTOXIN , -.

    Podophyllum peltatum

    : , .

    - -

  • Podophyllotoxin .

    Ph Eur (5R,5aR,8aR,9S)-9-[[4,6-O-[(R)-thylidene]-b-D-glucopyranosyl]oxy]-5-(4-hydroxy-3, 5-dimethoxyphenyl)-5,8,8a,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-6(5aH)-one-

  • Podophyllotoxin .

  • Vinca alkaloidsVinca rosea CATHARANTHINE

  • Vinblastine Sulphate Ph Eur

  • Vincristine SulphatePh Eur

  • (TAXOL)TAXUS BREVIFOLIA, TAXACEAE

    Paclitaxel 1960 . 1970 . 1994 .

  • , - ( )

    Prodrug drug.

    2007 Fosfestrol Sodiumtetrasodium (E)-4,4-(1,2-diethylvinylene)bis (phenyl orthophosphate)

  • 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate,Tamoxifen CitratePh Eur

  • Ph Eur (3RS)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione

  • Triptorelin Luteinizing hormone-releasing factor

  • Ph Eur cis-diamminedi-chloroplatinum (II)

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