Нестабильность генома у больных детским церебральным параличом

  • Published on
    05-Apr-2017

  • View
    216

  • Download
    2

Embed Size (px)

Transcript

<ul><li><p>2 6 3</p><p> , 2004 ., 85, 4.</p><p> 616. 988. 23 : 575. 113</p><p>.. , .. , .. , .. , .. </p><p> (. . .. ), (. . .. ) </p><p> - () , - - - , -, , - [1]. , - - -, ( - , -, , - - ) [1, 9].</p><p> -, - , - . , - , - - [10]. , , - , - (). - - - - , , - , - . - , - - - . -</p><p> - - - , - .</p><p> - - [14]. , - - - () .</p><p> : - .</p><p> 98 (59 39 ) - 40 (10 30 -). - . - 6 [1]. 23 (23,5%) (), 23 (23,5%) - (), 17 (17,7%) - (), 15 (15,3 %) - (), 12 (12,2 %) - (), 8 ( 8,2 %) -- (). e - ( 60%), , - -.</p><p> [15] - - - . - (30 ) , - -. 9070% 3 . - - 1:5 H 6,8 -</p></li><li><p>2 6 4</p><p> , 2004 ., 85, 4.</p><p> 20 . 1-2 , . 20 -, - .</p><p> () - 49 , 5. - 10 . - - . 9 , ( ) . - .. - . [2]. 48 . 3 - 0,5 /. 2 , - 150 , . -(, -) Sigma. - [3].</p><p> , - , . , , - - ( - ), - . , 1 2- ( - -) [3]. , , , , 0,05 200700 . , .. . [3] - , 10, 300 - .</p><p> STATISTIKA (Stat. Soft. I nc.1993, USA). - -, . :</p><p> Xmax Xmin K</p><p> i ,m Xmin - , , - : K=l+lgn. [6].</p><p> . - , - . . 1: - (0,05 (.1). , , - -, .</p><p> . - ( &gt;0,05), - . -, - - , (</p></li><li><p>2 6 5</p><p> , 2004 ., 85, 4.</p><p> - 2,12,9.-, - , . , - (m - 4 ) (, ) -- . , -, - ( ) - ( , 30 ). - - (. 1).</p><p> - - 2,5. - , - 2,7, 2,3, 2,2, 2,1. , - , . - , - - , (.. 2,9 ). 13 , -: 2 - - - , 12 .</p><p> . - -, </p><p>. 1. .</p><p>161511674</p><p>10</p><p>23231715128</p><p>40</p><p> 1</p><p>n ( m )</p><p>0,2120,009*0,2100,008*0,2010,014*0,1870,011*0,1880,007*0,2160,016*0,0880,014*</p><p>( M m ) ( M m )</p><p>0,2010,008**0,2190,017*0,2440,015*0,1980,009*0,2010,006**0,2040,012**0,0750,006*</p><p>0,2090,006*0,2130,007*0,2150,011*0,1930,007*0,1940,005*0,2100,009*0,0870,008*</p><p>n</p><p> , %</p><p>786954</p><p>30</p><p> (0,05 , ** &gt;0,05 .</p></li><li><p>2 6 6</p><p> , 2004 ., 85, 4.</p><p> 2,000,81 2,670,93 ( - ). - IX XX .</p><p> - , - ( ) - - . -, - - , 60 78%(. 2).</p><p> - . 8,24%, - 3 . , , , - -</p><p> - () . - , 6,190,42 6,390,51 - .</p><p> , -, , - - . - - . - (. 3). . - , - - .</p><p> - , - , -, -</p><p>. </p><p>7078706060</p><p>109</p><p>10101010</p><p> 2</p><p>%.</p><p>5,700,417,630,515,800,436,000,435,530,422,630,93</p><p>6,380,538,240,596,190,516,390,586,390,582,630,93</p><p>77766</p><p>n , %</p></li><li><p>2 6 7</p><p> , 2004 ., 85, 4.</p><p> . , - -, , - . [8, 11]. , - () - [8].</p><p> -, , , . , - - [12,13]. 2 - , - -, , 2+, , </p><p>, (, -) (,, - ), - [4]. - , . - - - (, , .).</p><p> , - (), - - , () - . </p><p>. 2. : - (), - (), ().</p></li><li><p>2 6 8</p><p> , 2004 ., 85, 4.</p><p>() . - - . , , . - (NMDA-) 80% . ( - ) . - (10-610-8 ) , 10-6 . - - - -.</p><p> - - - [7]. - -, , - - (. 2).</p><p> , - , . - - . - , , . - , - .</p><p>1. </p><p> - - .</p><p>2. .</p><p>3. - - - , -</p><p> - .</p><p>1. .., .., .. - . , 1988.</p><p>2. .., .., ..//. . 1984. 6. . 422428.</p><p>3. .. , .. - . .,1989.</p><p>4. .., .. . - -. ., 1998.</p><p>5. .., .., .. -. , 1992.</p><p>6. . . . ., 1980.7. .., .. . //.</p><p>. . . 2000. 1. . 2223. .</p><p>8. e .., .. .// -. 2003. 4. . 34 36.</p><p>9. .., .., .. . ., 1972.</p><p>10. ., . -. ., 1990.</p><p>11. .., .. . // . . . 2000. 6. . 43 48.</p><p>12. Finer N.N., Robertson C.M. et al. // J. Pediatr. 1981. Vol. 98. P. 112 117.</p><p>13. Hill A. // Pediatr. Neurol. 1999. Vol. 7(5). . 317 325.</p><p>14. Monreal F.J. // Dev. Med. Child. Neurol. 1985. Vol. 27. P. 325 330.</p><p>15. Schmid W. // Mutat. Res. 1975. Vol. 31. P. 915.</p><p> 12.01.04.</p><p>INSTABILITY OF GENOME IN PATIENTSWITH INFANTILE CEREBRAL PALSY</p><p>D.D. Gainetdinova, V.V. Semenov, M.F. Ismagilov,I.A. Pakhalina, E.V. Kolochkova</p><p>S u m m a r y</p><p>State of the genetic apparatus in patients withinfantile cerebral palsy is studied. The high level ofchromosomal aberrations and micronuclei is foundin peripheric blood cells. Clastogenic effect was notcorrelated with age and sex and was reliably higher ina group of children with double hemiplegia. Aneugeniceffect was similar in children with different forms ofthe disease and in different age groups. The authorsconnect the high intensity of clastogenesis andaneugenesis in patients with breaking of metaboliccycles of clastogenesis accompanied by the increasedgeneration of endomutagens and weakening ofantimutagenous protective system of genome.</p><p> /ColorImageDict &gt; /JPEG2000ColorACSImageDict &gt; /JPEG2000ColorImageDict &gt; /AntiAliasGrayImages false /DownsampleGrayImages true /GrayImageDownsampleType /Bicubic /GrayImageResolution 300 /GrayImageDepth -1 /GrayImageDownsampleThreshold 1.50000 /EncodeGrayImages true /GrayImageFilter /DCTEncode /AutoFilterGrayImages true /GrayImageAutoFilterStrategy /JPEG /GrayACSImageDict &gt; /GrayImageDict &gt; /JPEG2000GrayACSImageDict &gt; /JPEG2000GrayImageDict &gt; /AntiAliasMonoImages false /DownsampleMonoImages true /MonoImageDownsampleType /Bicubic /MonoImageResolution 1200 /MonoImageDepth -1 /MonoImageDownsampleThreshold 1.50000 /EncodeMonoImages true /MonoImageFilter /CCITTFaxEncode /MonoImageDict &gt; /AllowPSXObjects false /PDFX1aCheck false /PDFX3Check false /PDFXCompliantPDFOnly false /PDFXNoTrimBoxError true /PDFXTrimBoxToMediaBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXSetBleedBoxToMediaBox true /PDFXBleedBoxToTrimBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXOutputIntentProfile () /PDFXOutputCondition () /PDFXRegistryName (http://www.color.org) /PDFXTrapped /Unknown</p><p> /Description &gt;&gt;&gt; setdistillerparams&gt; setpagedevice</p></li></ul>

Recommended

View more >