ПОЗДНИЙ ГЕСТОЗ БЕРЕМЕННЫХ - ЗНАЧИМОСТЬ ИММУНОБИОХИМИЧЕСКИХ НАРУШЕНИЙ

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    04-Apr-2017

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<ul><li><p>112</p><p> 618.306; 612.017.1; 616002.2</p><p>.. , .. 1, .. , .. , .. , .. , .. </p><p> , 1 </p><p>E;mail: trunov1963@yandex.ru</p><p>LATE GESTOSIS OF PREGNANT SIGNIFICANCEOF IMMUNOBIOCHEMICAL DISORDERS</p><p>L.A. Trunov, O.G. Pekarev1, O.O. Obukhov, O.M. Gorbenko, A.P. Shvayuk, V.I. Shubina, A.N. Trunov</p><p>Scientific Center of Clinical and Experimental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk1Novosibirsk State Medical University</p><p> 80 : 60 20 . 1, 6 8, , / . 1. , . : , , , .</p><p>To study the features of immunobiochemical disorders in the pathogenesis of late gestosis of pregnancy, we studied 80women in the third trimester of pregnancy. 60 women were diagnosed with late gestosis, and 20 pregnant women withphysiological course of pregnancy. In women with late gestosis we revealed high concentrations of proinflammatorycytokines IL1, IL6, IL8, acute phase proteins lactoferrin and the ratio of proinflammatory / antiinflammatoryinterleukins. Also we revealed the high level of markers of cell destruction autoantibodies to antigen native DNA and</p></li><li><p>113</p><p>.. . ...</p><p>markers of endothelial dysfunction vascular endothelial adhesion molecule 1. Thus in the pathogenesis of late pregnancygestosis significant role is played by integrated development of the destructiveinflammatory process and endothelialdysfunction.Key words: late gestosis in pregnancy, pathogenesis, immunobiochemical disorders, cytokines.</p><p> , [1,2].</p><p> ,, , , [10]. , , .</p><p> , , , [4, 6, 8, 9].</p><p> , [3, 5, 7].</p><p> , , , , .</p><p> : .</p><p> 80 . 60 ( 28,21,13 ) 26 30 ; 20 ( 26,61,3 ) .</p><p> .</p><p> 1, 4, 6, 8 () .</p><p> 1 BenderMedsystems (Austria) .</p><p> .</p><p> . U . 95% (</p></li><li><p>114</p><p> , 2010, 25, 4, 2</p><p> , , , , 2, (p</p></li></ul>

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