СОВЕРШЕНСТВОВАНИЕ ТЕХНОЛОГИИ ПОЛУЧЕНИЯ ХИТОЗАНА

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<ul><li><p> . 11. 2011. 2 (2) 1 7</p><p> .</p><p>., </p><p>.., </p><p>2011</p><p> 663/66 36-9</p><p>.. , .. </p><p> . .</p><p> : , , -, , , , -.</p><p> I ., , - -. 1994 . 1 000 , 800 , - 150200 . . - , , , .</p><p> 15 , 70 - , - :</p><p>1. - , - -; - , , , , , ; , , .</p><p> [13] - . , - -, , , , . </p><p>, - , -. , , - - , - - / , - , - . - - . , -, , -, - .</p><p>, , - . , - , , - . -- - , -, - , - , . [6].</p><p>2. , ,, , - , -, -</p></li><li><p>1 8 .. , .. . </p><p> , - , ; - , - ; ; , - , - .</p><p>3. , , - , ,, [5], , , - .</p><p>4. -, 2540 %, -, , ; , - , -, - - .</p><p>5. , , , -, -, .</p><p> , - [2; 4] , , - , - , - , , - , (</p><p> ) , - .</p><p> - : - - , - , - , - , . - -, , .</p><p> -, , -, , , , - -, - (-), , -, - , , - , - , - , [9; 10; 14].</p><p> , , - , , - .</p><p> - , - N--2--2---D- [3] (. 1).</p><p> . - , </p><p>OO</p><p>N HH O</p><p>C OC H 3</p><p>C H 2O H</p><p>O O</p><p>N HH O</p><p>C OC H 3</p><p>C H 2O H</p><p>. 1. </p></li><li><p> . 11. 2011. 2 (2) 1 9</p><p> . - , - . - - - - . - . - - , - ( - ) , - , - - -. , , - , .</p><p> , - . - , - , - - .</p><p> , - Pandalus - , - Aspergillum.</p><p> - , - . - - - .</p><p> - - - 70 C, 20 C. , - 4 C, - .</p><p> - - , - , - , - .</p><p> (II) -(14)-2--2-D-, -, , 515 % , 1 % , - [12]. (I) 2 - (. 2).</p><p> , - - ( ) 2 3 - , .</p><p> , , </p><p>HO</p><p>O</p><p>NH</p><p>CO</p><p>CH3</p><p>OCH2OH O</p><p>NH</p><p>HO</p><p>+NaOH</p><p>O</p><p>CH2OH</p><p>CO</p><p>CH3</p><p>-CH3COONa OHO</p><p>CH2OHO</p><p>NH2</p><p>OCH2OH O</p><p>NH2</p><p>HO</p><p>(I) (II). 2. </p></li><li><p>2 0 .. , .. . </p><p> - 4049%- NaOH 110140 C 46 - [9; 11].</p><p> - , - , - , , . . [1; 8; 12].</p><p> - [7].</p><p> , - [9]. - , - , . -, , - , . - - . - - , - .</p><p> , - , - , , .</p><p> - ( 50 C), - - , , .</p><p> -- (. ) -</p><p> - -, - , , .</p><p> , - , -, - ,, - - .</p><p> - . 10 %- - , , - : -, -. - - - .</p><p> 0,1 M l. - - , .</p><p> - 12 23 - , - - , 40%- NaOH ( - 1 : 20) 100 C - 12 .</p><p> - -</p><p>- . . </p><p> % 10,0 9,40 1%- 2%- </p><p>. 7,5 3,85 </p></li><li><p> . 11. 2011. 2 (2) 2 1</p><p> . 2001. . 7, 1. . 5156.</p><p>4. , . . - / . . // . 2005. 5. . 2127.</p><p>5. --. , , - / . . [ .] // . 2000. 6. . 1418.</p><p>6. , . . - / . . , . . -, . . // . 2005. 6. . 2124.</p><p>7. / .. . . . : . ., 1984. 255 .</p><p>8. . 2116314 , 6 08 37/08. / . . -, . . , . . , . . -. 97104789/04 ; . 26.03.97 ; . 27.07.98// . 1998. 21. 220 .</p><p>9. . , / . . . , . . -, . . . . : , 2002. 368 .</p><p>10. Chitosan as antimicrobial agent: applicationsand mode of action / E. Rabea, M. Badawy, C. Stevens,G. Smagghe [et al.] // Biomacromol. 2003. Vol. 4, l. P. 1457.</p><p>11. Chitosan Preparation from Persian Gulf ShrimpShells and Investigating the Effect of Time on the Degreeof Deacetylation / M. Shahabi Viarsaghl, M. Janmaleki,H. Reza Falahatpisheh1, J. Masoumi // Journal ofParamedical Sciences (JPS). 2009. Vol. 1. P. 27.</p><p>12. Hoemann, C. Tissue engineering of cartilageusing an injectable and adhesive chitosan-based cell-delivery vehicle / C. Hoemann, J. Sun, A. Legare// Osteoarthritis Cartil. 2005. Vol. 13. P. 318329.</p><p>13. Kyung, W. K. Antimicrobial activity of nativechitosan, degraded chitosan-carboxymethylatedchitosan / W. K. Kyung, R. I. Thomas, L. Chan // Journalof Food Protection. 2003. 66. P. 14951498.</p><p>14. Ultrastructure of hybrid chitosan-glycerolphosphate blood clots by environmental scanning electronmicroscopy / M. Iliescu, C. D. Hoemann, M. S. Shive,A. Chenite // Microsc. Res. Technique. 2008. Vol. 71, 3. P. 236247.</p><p> . -, 70 %. - 5055 .</p><p> - Pandalus . - 8,6 %, 6,46 %, 43,8 %, 40,9 %.</p><p> - , - ( 9289-067-00472124-03). - :</p><p> : 13 .: .: ,</p><p> .: ,</p><p> . </p><p> pH- - pH-150 .</p><p> 100105 .</p><p>1. , . . - : , - / . . , . . // - . , . . : , 2002. C. 723.</p><p>2. , - / .. [ .]// . 1995. 6. . 1822.</p><p>3. , . . : -, , / . . // -</p><p>IMPROVED TECHNOLOGY OBTAINING CHITOSAN</p><p>M.P. Lyabin, P.S. Semenov</p><p>The main applications of chitosan. The possibility of obtaining biopolymer new soft way.</p><p>Key words: chitin, chitosan, medicine, biotechnology, bioengineering, production,deacetylation.</p></li></ul>

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