ВАКУУМ-ТЕРАПИЯ В ЛЕЧЕНИИ ХРОНИЧЕСКИХ РАН

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  • 453/2012

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    Vacuum therapy for chronic woundsZaytseva E.L., Tokmakova A.Yu.Endocrinology Research Centre, Moscow, Russian Federation

    Chronic wound in patients with diabetes mellitus (DM) is one of the most urgent problems of modern diabetology and surgery. Number of patients suffering from different types of chronic wounds follows increase in DM incidence. Vacuum therapy is a novel perspective method of topical treatment for non-healing chronic wounds of various etiology. Current review addresses experimental and clinical evidence for this method.Key words: diabetes mellitus, chronic wound, vacuum therapy, growth factors

    . 2012;(3):4549

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    1. . . ; 2000. 672 .2. Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pec-

    oraro RE, Rodeheaver G, Robson MC. Definitions and guide-lines for assessment of wounds and evaluation of healing. Arch Dermatol. 1994 Apr;130(4):489493.

    3. Reiber GE. Epidemiology of foot ulcers and amputations in the diabetic foot. In: Levin and O`Neal`s The Diabetic Foot (6th ed.). Mosby; 2001. p.1332.

    4. Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N, Rei ber GE, Wagner EH. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care. 1999 Mar;22(3):382387.

    5. . - . . : ; 2000. 96 .

    6. Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacu um-assisted closure: a new method for wound control

    and treatment: clinical experience. Ann Plast Surg. 1997 Jun;38(6):553562.

    7. Wackenfors A, Sjgren J, Gustafsson R, Algotsson L, Ingemans-son R, Malmsj M. Effects of vacuum-assisted closure therapy on inguinal wound edge microvascular blood flow. Wound Re-pair Regen. 2004 NovDec;12(6):600606.

    8. Chen SZ, Li J, Li XY, Xu LS. Effects of vacuumassisted closure on wound microcirculation: an experimental study. Asian J Surg. 2005 Jul;28(3):211217.

    9. Timmers MS, Le Cessie S, Banwell P, Jukema GN. The effects of varying degrees of pressure delivered by negative-pressure wound therapy on skin perfusion. Ann Plast Surg. 2005; 55 (6): 665671.

    10. Ono I, Gunji H, Suda K, Iwatsuki K, Kaneko F. Evaluation of cytokines in donor site wound fluids. Scand J Plast Reconstr Surg Hand Surg. 1994;24:269273.

    11. Morykwas MJ, Faler BJ, Pearse DJ, Argenda LC. Effects of vary-ing levels of subatmospheric pressure on the rate of granulation

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    tissue formayion in experimental wounds in swine. Ann Plast Surg. 2001;47(5):547551.

    12. Fabian TS, Kaufman HJ, Lett ED, Thomas JB, Rawl DK, Lewis PL, Summitt JB, Merryman JI, Schaeffer TD, Sargent LA, Burns RP. The evaluation of subatmospheric pressure and hyperbaric oxy-gen in ischemic full-thickness wound healing. Am Surg. 2000 Dec;66(12):11361143.

    13. Walgenbach KJ, Starck JB. Induction of angiogenesis following vacuum sealing. ZfW. 2000; 13:910.

    14. Isago T, Nozaki M, Kikuchi Y, Honda T, Nakazawa H. Effects of different negative pressures on reduction of wounds in negative pressure dressing. J Dermatol. 2003 Aug;30(8):596601.

    15. Genecov DG, Schneider AM, Morykwas MJ, Parker D, White WL, Argenta LC. Pressure dressing increases the rate of skin graft donor site reepithelisation. Ann Plast Surg. 1998 Mar;40(3):219225.

    16. Kopp J, Hoff C, Rosenberg B, et al. Application of VAC therapy upregulates growth factor levels in neuropathic diabetic foot ulcers. Wound Repair Reg. 2003;11(5):0.007.

    17. Shi B, Chen SZ, Zhang P, Li JQ. Effects of vacuum-assisted clo-sure (VAC) on the expressions of MMP-1, 2,13 in human gran-ulation wound. Zhonghua Zheng Xing Wai Ke Za Zhi. 2003 Jul;19(4):279281.

    18. Mous CM, Vos MC, van den Bemd GJ, Stijnen T, Hovius SE. Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen. 2004 JanFeb;12(1):1117.

    19. Augustin M, Herberger K. Benefits and limitations of vacuum therapy in wounds. Hautarzt. 2007 Nov;58(11):945951.

    20. Ngo QD, Vickery K, Deva AK. The effect of topical nega-tive pressure on wound biofilms using in vitro wound model. Wound Repair Regen. 2012 JanFeb;20(1):8390. doi: 10.1111/j.1524475X.2011.00747.x. Epub 2011 Nov 29.

    21. Buttenschoen K. Fleischmann W, Haupt U, Kinzl L., Butten-schoen DC. The influence of vacuum-assisted closure on inflam-matory tissue reactions in the postoperative course of ankle fracture. Foot Ankle Surg. 2001;7(3):165173. http://dx.doi.org/10.1046/j.1460-9584.2001.00258.x

    22. Morykwas MJ, Howell H, Bleyer AJ, Molnar JA, Argenta LC. The effect of experimentally applied subatmospheric pressure on serum myoglobin levels after a prolonged crush/ ischemia injury. J Trauma. 2002;53(3):537540.

    23. Schintler MV. Negative pressure therapy: theory and practice. Diabetes Metab Res Rev. 2012 Feb;28 Suppl 1:7277.

    24. Expert Working Group. World Union of Wound Healing Societ-ies Initiative. Vacuum assisted closure: recommendations for use. A consensus document. Int Wound J. 2008. 10.

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    . 2012;(3):4549

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