Соединения металлов в живой природе

  • Published on
    08-Dec-2016

  • View
    213

  • Download
    1

Embed Size (px)

Transcript

  • , 9, 1997

    48

    . .

    . ..

    . , , , , -, . - , -. , , - .

    , :

    1) ( . 1), , . , , , , , -;

    2) - , - . , , - ;

    3) , - , - ,

    METALLOCOMPOUNDSIN LIVING NATURE

    D. A. LEMENOVSKI

    The main problems ofmetal derivatives and liv-ing cell interaction arediscussed. These prob-lems include the environ-mental cycle of metals;metals as poisons andnonpoisons; transport ofmetals through the cellmembranes and molecu-lar mechanism of metalaction on complicatedbiomolecules.

    fl - -fl -. - - - , fl fl, - , -fl fl-fl - -.

    ..,

    1997

    Cs Ba La Zr Ta W Re Os Ir Pt Au Hg

    Rb Sr Y Hf Nb Mo Tc Ru Rh Pd Ag Cd

    K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn

    Na Mg

    Li Be

    . 1.

  • ..

    49

    , - .

    - , , - . - , - , , - .

    , , -. , - - , , - , . , - (As) - , - . (CH

    3

    )

    3

    As

    +

    CH

    2

    COO

    - , .

    (Zn) 1015 . , , Zn

    2+

    , - . - Zn

    2+

    - :

    -, -- 200 , . - -. , , - . , Hg

    2

    l

    2

    , ,

    PO O

    O O CH2 CH2 OP

    OZn O

    O

    CH2

    CH2 OP

    O

    O

    O

    CH2 CH2 OP

    O

    O

    OZn

    , .

    , , -. . - (. 2).

    -, - -. -, , - -. . , , , - . -: ? , .Me

    2

    Hg - , , . - , Me

    2

    Hg MeHg

    +

    70 45 Hg

    2+

    . - , , .

    , - - .

    CH

    4

    + C

    2

    H

    6

    Me

    2

    Hg Hg

    0

    Hg

    2+

    MeHg

    +

    Me

    2

    HgMeHg

    +

    Hg

    0

    .

    Hg

    0

    Hg

    2+

    Hg

    22+

    HgS HgS

    22

    . 2.

    1

    1

    -, , .

  • , 9, 1997

    50

    , -, , -. - . -, - , , -, . , , , - .

    MeHgX, EtHgX

    RHgX (X = Ac, Py

    +

    ) - , -

    PhHgX ,

    MeOCH

    2

    CH

    2

    HgX

    ( EtHg

    +

    )

    (- )

    X .

    , , , . , .

    - , - - , :

    Me

    4

    Sn + Hg

    2+

    MeHg

    +

    + Me

    3

    Sn

    +

    Me

    4

    Si + Hg

    2+

    MeHg

    +

    + Me

    3

    Si

    +

    - - . , , , - (, ,), - .

    - , - , - . - . , , .

    - , . - Na

    +

    K

    +

    , - . , , , Na

    +

    , 23187 Ca

    2+

    ( - , , ), - (. 4).

    . 5 - . , - . - ( )

    O

    O

    OP

    OH

    MeC

    CH2

    NH

    CO

    H2NOC

    H2C

    CH2

    CH2 Me

    CONH2

    CH2

    CH2

    Me

    Me

    Me

    N N

    NN

    H

    H

    H

    H

    H

    H

    MeMe

    H2C

    H2NOC

    CH2

    CH2

    CONH2

    Me CH2

    CONH2

    Me

    CH2

    CH2CONH2

    Co

    Me

    Me

    Me

    H

    HN

    NH

    OH

    OH H

    H

    HOH2C H

    Me[Co] + Hg2+ MeHg+ + [Co]+

    . 3.

    [] (CoC

    63

    H

    91

    N

    13

    O

    14

    P)

    , - . , - , MeHg

    +

    (. 3).

  • ..

    51

    () . Na

    +

    , K

    +

    , , - . -, , - -, , , .

    , - . , - -, . -. , , . , .

    ( )

    ? , , , -

    , . , , (. 6), - .

    , - . - -, , - (. 1).

    - , - , . - - , , , -. , , , -. . 2.

    O O O O O

    MeMe

    Me

    Me Me

    MeMe

    OH

    HO

    CO2H

    HH H H H

    CH2OH

    Et N

    O

    O

    O

    MeH

    H

    H

    H Me

    MeN

    OH

    NHMeCO2H

    A23187

    . 4.

    Na

    +

    +

    . 5.

    N N

    N N

    H N N

    N NHH

    N N

    N N

    HH

    N N

    N NH

    . 6.

    -

  • , 9, 1997

    52

    - ? - , - . - () .

    , :

    PtCl

    Cl

    H3N

    H3NPt

    H3N

    H3N

    O

    O

    C

    C

    O

    O

    --. , -

    - - :

    - .

    . - - , - . . 7 , .

    . 7,

    . . 7,

    , - -. . 7,

    , . - . , - . - -

    ( )

    , - . , -.

    , - . -, , -, . 1. - 10 000

    N

    NPt

    O

    O

    O

    O

    H2

    H2

    PtCl

    Cl NH3

    H3N

    1.

    Na, K - ()

    Mg, Ca -

    Zn, Ni (Zn)

    - -

    -- -

    Fe, Cu

    2.

    ,

    /

    ,

    /

    ,

    /

    .

    ,

    /

    .

    Na 1,5 1960 300 26008000

    Mg 0,3 24 590 900

    Ca 15 61 100360 140700

    Cr 0,03 25 0,023,3 0,0240,084

    Fe 60 450 2501400 180

    Zn 2040 0,29 0,232,3 0,332,4

  • ..

    53

    ...

    ......

    ...

    ...

    ...

    ...

    ......

    ...

    ...

    ......

    ...

    ...

    ......

    ......

    ...

    ...

    ...

    ...

    ......

    ...

    M

    ...

    ...

    ...

    ...

    ......

    ...

    ...

    ...

    ...

    ...

    ...

    ...

    ...

    ......

    ...

    ...

    ...

    ... ...

    ...

    ......

    ...

    - 68. - ., , , , - .

    , - , . . - , - .

    1.

    Sadler P.J

    . Inorganic Chemistry and Drug Desigh // Ad-vances in Inorganic Chemistry / Ed. A.G. Syker. L.: Acad.Press, Inc. 1991. Vol. 36. P. 148.

    2.

    Hughes M.N

    . Coordination Compounds in Biology //Comprehensive Coordination Chemistry / Ed. G. Wilkin-son. N.Y.: Pergamon Press, 1987. Vol. 6. P. 515765.

    3.

    Craid P.J

    . Environmental Aspects of OrganometallicChemistry // Comprehensive Organometallic Chemistry /Ed. G. Wilkinson. N.Y.: Pergamon Press, 1987. Vol. 2.P. 9791020.

    4.

    .

    .,

    ..

    -. 2-e . .: , 1991.

    * * *

    ,

    , -

    . .. .

    . 125 .

    . 7.

Recommended

View more >