Комплексы металлов в живых организмах

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  • ..

    27

    . .

    -

    - - . - (, , ,), - . -? ,

    d

    -

    f

    - . - , , ( ) . - . , . - ( ) , , , .. [1]. - , , - . 1. - , - ; .

    - , , , - , =CH-:

    THE METAL COMPLEXES IN LIVING ORGANISMS

    N. A. ULAKHOVICH

    The biochemical proper-ties of vitally importantmetal complexes are con-sidered. Experimental evi-dence concerning themolecular structure ofmetalloproteins and theirrole in oxygen transporta-tion as well as in the regu-lation of enzyme activityare presented.

    - - . fl fl - , fl .

    .

    ., 19

    97

  • , 8, 1997

    28

    1

    . - , - , - , 4 8 . -, (). 15 . - : , -,

    12

    . - . - ,

    NH N

    HNN

    1

    2 3

    4

    5

    67

    8

    I II

    IIIIV

    , .

    , - , N

    4

    , 2

    -

    2+

    ,

    3+

    ,

    4+

    . - , , , - . N

    4

    xy

    , MN

    4

    , - , N

    4

    , - (L)MN

    4

    ( 2) (L

    1

    )(L

    2

    )MN

    4

    (- 3) .

    2

    L

    N N

    N

    M

    N

    1.

    ,

    -

    O , ;

    O , ;

    O , , . -

    O , , .

    ; ; -

    O ; ( )

    , N, S , , ,

    N, S ,

    N, S H CH

    3

    -, ,

    12

    N, S ,

    N, S , ,

    2

    N, S 70 ,

    N, S , ,

  • ..

    29

    3

    -, , - - L. M L

    xy

    , - N

    4

    . (L), - , , .

    - - () , - . - - .

    , - - . , , . - () [2]. - .

    -. [3]. , , () - Fe(II):

    N

    N NN

    L1

    M

    L2

    4

    (Im) , - . - , , -, (- .). . -, (), , , . - , , , - .

    N N

    NN

    Fe

    CH CH3

    CH3

    CH CH2

    CH2

    H3C

    H3C

    CH2)2COOHC)2 (HOOC(H2

    N

    N N

    NN

    Fe

    O

    2

    N

    . 1.

  • , 8, 1997

    30

    - . - - - . - , , , .

    Fe(II) - 5, -- - - (. 1). Fe(N)

    4

    N

    Im

    , 0,8

    . - (

    2

    ), . -

    2

    , , Fe(II). Fe(N)

    4

    N

    Im

    - Fe(N)

    4

    N

    Im

    (O

    2

    ).

    N-- , -

    (I

    m

    O

    2

    ) - Fe(II) -

    [4].

    g

    - - .,

    2

    - Fe(II) -

    -. - ,

    d

    yz

    (

    d

    zx

    -)-, ()

    p

    z

    -

    2

    .

    -Fe(II) O

    2

    -

    - . - - N

    4

    . , - Fe(II) , , - . - , - , , - . , - , , -, :

    HbO

    2

    + CO = HbCO + O

    2

    ,

    Hb + CO = HbCO,

    Hb .

    t2g4 eg

    2

    t2g6 eg

    0

    (HbCO) . CO - Fe(II), O

    2

    . - (, ) CO.

    , 3+. . - (- , , ). - - . , . - .

    , , , - (- ). () - . , - . , , , -. O

    2

    H

    +

    (. 2). - , , . - - . Fe

    3+

    + e = Fe

    2+

    , Fe

    2+

    e == Fe

    3+

    - .

    :

    a

    ,

    b

    c

    .

    c

    , - . , (II) ,

    Fe

    2+

    2 .

    b

    Fe

    3+

    (

    H

    2

    )

    2H

    +

    Fe

    3+

    2 .

    c

    1

    Fe

    2+

    Fe

    2+

    2 .

    c

    Fe

    3+

    Fe

    3+

    2 .

    a

    Fe

    2+

    Cu

    +

    2 .

    a

    3

    Cu

    2+

    1/2 O

    2

    O

    2

    H

    2

    O

    . 2.

    . , .

  • ..

    31

    .

    c

    , - - . -

    c

    a

    a

    3

    . - . , , - :

    5

    - , , - - O

    2

    [5]. , . , (), .

    12

    , (. , ), 2,5

    10

    4

    /. - - . 1926 -, . , 1948 , - , - . . -

    N N

    NN

    Fe

    CH3

    CH3

    CHH3C

    C

    CH2

    H

    H

    H

    H

    CH2CH2CH2CC

    OO OH OH

    O

    H

    CH2

    CHO C

    CC

    CC

    CC

    CC

    CC

    CCH3

    CH3 CH3 CH3

    H H HH2

    H2

    H2

    H2 H2

    H2

    (II)

    A

    () :

    6

    - , -, =CH, - . (II) , (II). , .

    12

    , CN- - .

    12

    - . -

    12

    ( 90% ) , . - CN- -:

    7

    B12

    CH

    CH2

    NH

    CO

    CH2

    CH2

    OP

    CC

    N

    H

    HH

    H

    H

    CH3

    CH3

    CH2CH2

    CH3

    CH3

    CH2

    CH2

    CH2C

    CC

    C

    CC

    C

    C

    C

    CCH2CH2

    C

    N

    N

    C

    C

    N

    N

    OH

    HH

    H

    H

    OO

    O

    O

    C

    Co+

    N

    CON H2

    CON H2

    CH2 OH

    H3

    H

    H2NO

    H2

    H2NOH3

    H2NOH2

    H3

    H3

    H3

    N

    H2NO

    A

    B

    C

    D

    H3

    H3

    NH2

    N

    N

    N

    NOH

    H

    CH2 H

    H

    HH

    O

  • , 8, 1997

    32

    12

    -. , - . , - - , CH

    3

    . - , , , [6]. - - .

    - , . - , - -

    -. , - - . - - , , - - .

    1.

    . . .: , 1975. 237 .

    2.

    .

    .,

    .

    . ..: , 1988. 160 .

    3.

    .

    . . .: .., 1978. 381 .

    4.

    .,

    .

    ,

    . -. .: , 1983. 360 .

    5.

    .,

    ., ., ., . - . .: , 1981. . 1. 534 .

    6. . . .: , 1969.

    * * *

    , - , . : - , - ( - , - ), - . 350 , .

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