ГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ N-АЦЕТИЛТРАНСФЕРАЗЫ У БОЛЬНЫХ ДЕТСКИМ ЦЕРЕБРАЛЬНЫМ ПАРАЛИЧОМ

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<ul><li><p> , 2006 ., 87, 4</p><p>261</p><p> , - , - , , . - - , , .. . [6]. , - , - . , - - . , - - , , - [2].</p><p>.. , - - . : -, - - -. (), -, , - - , - . - - , - -.</p><p> 616. 988. 23 + 616. 831 009. 11] 07 : 577. 152. 22</p><p> N- </p><p>.. , .. , .. , .. , .. </p><p> , (. . .. ),</p><p> (. . .. ), </p><p> (. . .. ) </p><p> - , - - . - N- (N-AT), , , [7, 8, 9].</p><p> - (rr) - , - (RR) - (Rr) . - , [7, 10, 11].</p><p> N-- , - - .</p><p> 89 - 8 18 20 , - -. N-AT - -- ( ,). - 10 /, - [1] - 2 . 0,3 -, 7,7 - 2,0 -, - (-46) - - . - -</p></li><li><p> , 2006 ., 87, 4</p><p>262</p><p> : 7% , 7,1% [3, 4].</p><p> - - [5].</p><p> - , (.1). 84,3%, (25,0%; p</p></li><li><p> , 2006 ., 87, 4</p><p>263</p><p> - ( ). , N-AT - , .. 7,0% (=5,1 = 5,6 ), - - (=0,8 = 1,0 ). , - - N-AT .</p><p> . 4 N-AT . () - - ( -). - N-AT - - .</p><p> N-AT : (-</p><p>. 2. N- ( , %).</p><p>. 3. - ( , 25 75-). * N-AT .</p><p>. 4. N-AT . * (</p></li><li><p> , 2006 ., 87, 4</p><p>264</p><p> . (40,0%) (31,6%) -. N-AT (64,3%) - .</p><p> , - . - - . - - -. - (R) - .</p><p>1. - - , - N-AT.</p><p>2. - .</p><p>3. ( N-AT 7,1% ) 16,2.</p><p>1. - . / . .. 2 . ., 2001..2. . 246.</p><p>2. .. </p><p> : . . . . . . ., 1985.</p><p>3. .., .., .., ..//. . -. , 2004. 1-2. . 7481.</p><p>4. .., .. . // -. . . 2005. 3.. 2937.</p><p>5. . - . /. . ., 1998.</p><p>6. .., .. // . -. . 1990. 9. . 125126.</p><p>7. .. N- - - : . . . . . , 2001.</p><p>8. Butcher N.J., Arulpragasam A., Minchin R.F. //J. Biol. Chem. 2004. May 21.Vol. 279 (21).P. 2213122137.</p><p>9. Furet Y., Bechtel Y., Le Guellec C. et al. //Therapie. 2002. Sep-Oct.Vol. 57 (5). P. 427431.</p><p>10. Rey E., Gendrel D., Treluyer J.M. et al. //Fundam. Clin. Pharmacol. 2001. Oct. Vol.15. P. 355359.</p><p>11. Seifart H.I., Parkin D.P., Botha F.J. et al. //Pharmacoepidemiol Drug Saf.2001. Mar-Apr. Vol.10. P. 127134.</p><p> 09.03.06.</p><p>GENETIC POLYMORPHISM OF N-ACETYL-TRANSFERASE IN PATIENTS WITH CHILD</p><p>CEREBRAL PALSY</p><p>D.D. Gainetdinova, V.V. Semenov, M.F. Ismagilov,I.A. Pakhalina, V.I. Pogorelcev</p><p>S u m m a r y</p><p>Activity of N-acetyltransferase was studied in 89</p><p>children with child cerebral palsy (CCP). Patients with</p><p>CCP were predominantly low acetylisers. Children with</p><p>a fast acetylisation process had relatively low incidence</p><p>and milder type of CCP. A risky group for CCP includes</p><p>those children who have the activity of N-acetyl-</p><p>transferase of 7.1% and higher and with unfavourable time</p><p>course during intra-uterine and perinatal periods. An</p><p>index to calculate the relative risk to have CCP for</p><p>patients with low type of acetylation was introduced.</p><p> 2</p><p>. . .% % %</p><p>28,640,327,8</p><p>4235</p><p>11612</p><p>7,128,1*66,7*</p><p>145718</p><p>100,0100,0100,0</p><p>* &lt; 0,05.</p><p>. %</p><p>64,331,65,5</p><p>9181</p></li></ul>

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