ChemInform Abstract: Pyrrolidines Bearing a Quaternary α-Stereogenic Center. Part 1. Synthesis of Analogues of ABT-418, a Powerful Nicotinic Agonist

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  • 1999 isoxazole derivatives

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    44 - 135Pyrrolidines Bearing a Quaternary -Stereogenic Center. Part 1.Synthesis of Analogues of ABT-418, a Powerful Nicotinic Agonist. Starting with the pyridine derivative (I), the aminoaldehyde (VI) issynthesized as the key compound by ring contraction of the enamine (V).Standard procedures are used to convert (VI) into racemic ABT-418 (VII)and various analogues, e.g. (VIII)(X). (GIARD, THIERRY; LASNE,MARIE-CLAIRE; PLAQUEVENT, JEAN-CHRISTOPHE; Tetrahedron Lett.40 (1999) 30, 5495-5497; Inst. Rech. Chim. Org. Fine, CNRS, Fac. Sci., Univ.Rouen, F-76821 Mont-Saint-Aignan, Fr.; EN)

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