GFS Chemicals Chromatography Brochure

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<ul><li> 1. Specialty ChemicalManufacturing Expertise Since 1928GFS ChemicalsChromatographyProducts2006-2007 PRODUCT CATALOG</li></ul><p> 2. Products For ChromatographyAnd Material Separation/ PurificationThe GFS tradition of personal Specialty Silicas, Florisil, Ion Exchangeservice and attention to detail Unmodified, 40, 60, 90, andResins (p. 134-135)has attracted the attention of150 Angstrom, GFSelectTM Drierite, Activatedexperts in chromatography grade (page 130), Bio- Carbons, Diatomaceouswho have long seen a need for refinedTM qualified by Earths (page 136) CHROMATOGRAPHYthis type of commitment toRNase, DNase and Protease Specialty Reagents forproblem solving in separation testing. Chromatography (page 137)sciences. Our alignment with Aluminas (Brockmann I: Bio-RefinedTM Productsthe entrepreneurial resources Acidic, Basic, and Neutral); (page 138)of Diazem Corp. (Midland, MI) W. R. Grace silicas (page Royer Anion Exchangehas already provided industry 131-132) Resins and Precious Metalwith practical solutions to Silica Gel Desiccants; Catalysts (page 139)environmental and process Molecular Sieves (page 133)problems. We invite you totalk to us about using this Diazem MCACportfolio of novel technolo- Flow through a Stainlessgies to address your materials Removal of Pt steel Column of anrecovery or separationsfrom a fluid stream aqueous solution of Pt (0.01M) gave capture ofissues (note example at right).0.029g of Pt on 0.3g of media which is 9.9% Pt Custom Modified Silicas forrelative to the mass of the media.Tough SeparationsProblems (page 124)Measurement of the effluent showed less thanDiazem/Dow tailored200ppb Pt at the baselinetechnologies for the effluent. HPLC Solvents (page 126) Macherey-NagelNUCLEOSIL, NUCLEODUR,unmodified spherical andirregular silica gels (page127-130) Plus access to the 27 3645full Macherey-Nagel Line of 0 9 18mL of 0.1M PtTLC and ColumnChromatography Products 3. Silicas for Advanced The VisionThe GFS Connection Separations from DiazemDiazem and the Dow Chemical The GFS commitment to offer Technologies Co. have announced a jointseveral prominent lines of sili- All the chromatographic sili-technology and licensingcas, including Macherey-Nagel cas on the following pages are agreement that will provide and W. R. Grace products, capable of being modified by the bio-tech market with spe- gives separations scientists a technology recently patented cialty chromatographicbroad base of qualified prod- by Diazem Corp. The resultingsorbents and engineeringucts, traceable by lot analysis products frequently allowprocesses. This includes aunder ISO-certification, which chromatographic separationscritical range of state-of-the- may ultimately be enhanced that are unattainable by stan- art separation capabilities by Diazem/Dow technology. dard silica media. This novelsuitable for geometric andYour customized project can silica/silane surface chemistryoptical isomeric molecules, be managed from research toCHROMATOGRAPHY exhibits a utility and, more peptides and proteins. This commercialization with com- importantly, a predictability in technology will impact theplete confidence in the consis- solving real-life problems most challenging issues oftency of quality of the sorbent faced in separation science. analytical and preparativeof your choice. GFS technicalchromatography, and address and product support bothindustry needs from drug dis- help provide a new gateway The Technologycovery to problem solving in cutting- Diazems Dual ZoneTM Materialedge separation sciences. technology uses pore-diffu- sion control silylation with Unique Diazem Products two (or more) silane bonding Despite the customized agents to give selective bond- nature of Diazem products, ing of one chemical composi- GFS offers a selection of C-18 tion on the outer zone of aDiazem modified silicas for porous material and a differ-your consideration. These ent chemical composition oninclude substrates with poly- the inner zone. Each zonemeric/hydrophilic character then has a different chemicaluseful in pharma-biotech sep- reactivity, and the processarations. New Diazem metal also allows for better silanol chelating media are also avail- control. Sorbents tailored via able from GFS. Please check in this technology can separate the alphabetical section under diverse materials, especiallyDiazem. biological substrates, more completely and efficiently than standard separations media. 4. New Diazem CorporationThese resins have also shown Recovery of precious metalsChelation Technologythe ability to remove radioac- Removal of metals that Diazem Corporations new tive radium from a contami- could otherwise interfereChelation adsorbent contin- nated source. The Diazemwith analytical proceduresues to show promise in sever- MCAC phase reduced the Purification of product oral markets. radium levels from 15 picoproduct streamscuries to less than 1 pico Removal or recovery ofThe new materials, referred tocurie. Mercury levels wereorganic and inorganic acidas metal chelation and acidreduced to below ppb levels.contaminantscapture (MCAC) phases, are Separation of proteins,based on the immobilization The MCAC phases are anpeptides, or nucleotidesof hyperbranched macromole- important extension of Removal of anion contami-cules on various supportDiazems unique, proprietarynants such as phosphatesDual ZoneTM Materials CHROMATOGRAPHYmedia. These phases offerthe advantage of effectivelyTechnology. In Dual ZoneTMDiazem Corporation has takenremoving metal cation and Materials, silanes are chemi- classical silane, surface sci-anion contamination fromcally bonded to porous silica ence and polymer chemistrieschemical processes, waste-support media by preciselyand used them in unconven-water discharge, and drinking controlling coverage density, tional ways to address marketwater. In addition, the materi- silanol capture and phase needs. Feel free to contactals are very effective acid polarity. Dual Zone Materials GFS regarding possible appli-scavengers. Applicationscan be chemically tailored to cations of interest to you.include removal of Fe, Co, Ni,achieve a range of separationCu, Zn, Pt, Pd, Pb, and Hg. Ptgradients for a variety of com-removal is carried out at a plex separations.rate up to 20% relative to theweight of the media.Anions can be removed withsimilar efficiency by usingDiazem Anion Capture Phase.The possible uses of thesematerials include: Recovery of transition-metalcomplexes used in homoge-neous catalytic processes Treatment of waste streamsto remove low levels oftoxic anions 5. HPLC &amp; Specialty Solvents GFS has decades of experi- ence with chemical distilla- tions, both organic and inor- ganic. Our growing experience with the Farchan LaboratoriesCHROMATOGRAPHY line of acetylenic and olefinic research intermediates has given us even more insights into the purification of volatile, moisture and temper- Each of our specialty solventscapillary gas chromatography ature sensitive materials. The is carefully analyzed and certi-with electron capture and grades of solvent offered in fied to meet our publishedflame ionization detectors. this catalog cover a full rangespecifications. The quality of of applications and sensitivi- each solvent far exceedsUltra Low Cut-off, Distilled in ties. These include products reagent specifications set by Glass Solvents consistently that are distilled-in-glass or the American Chemical pure solvents for: quartz, and HPLC solventsSociety. Quality is controlled HPLC where the emphasis is on not only by UV Spectro- Gas Chromatography High Performance.photometry, but also by Pesticide Residue Analysis SpectrophotometryMin Assay % (by GLC) Max WaterMax UV Cutoff Max Residue ACETONE 99.70.50%330nm 3ppm ACETONITRILE99.70.02%190nm 3ppm CHLOROFORM99.70.02%245nm 3ppm CYCLOHEXANE 98.50.01%195nm 3ppm DICHLOROMETHANE 99.80.01%233nm 3ppm ETHYL ACETATE 99.60.05%256nm 3ppm ETHYL ETHER 99.50.08%218nm 3ppm FORMIC ACID 88.0N/AN/A 1ppm HEPTANE 99.50.01%200nm 3ppm HEXANE___ 0.01%200nm 3ppm METHANOL99.80.08%205nm 3ppm PENTANE 98.50.01%195nm 3ppm PETROLEUM ETHER ___ 0.02%____3ppm ISOPROPYL ALCOHOL 99.50.10%205nm 3ppm TETRAHYDROFURAN 99.70.03%215nm 3ppm TOLUENE 99.70.03%284nm 3ppm 2,2,4-TRIMETHYLPENTANE99.70.02%210nm 3ppm 6. New Math ForSilica Gel and Chromatography ProductsMACHEREY-NAGEL...90+Years in Products forChromatography Markets.GFS CHEMICALS 70+ YearsServing Analytical andCHROMATOGRAPHYResearch MarketsIt Adds Up...Partners with160+ years of combined expe-rience, just a phone call away.GFS is your gateway to a hostof chromatography productsfrom Macherey-Nagel GmbH, aleader in the development ofmedia and other products forseparation sciences for over90 years. GFS stocks a wideLarger quantities of these their consistent and well-range of M-N unmodifiedmaterials are also available.defined character:media, including such popularPlease let us know how wetrademarked brands ascan help you. High bed stability due toNUCLEOSIL, NUCLEODUR, spherical particle shapePolygosil, and Polygoprep. NUCLEOSIL Products High efficiency due toWhen your needs extend to narrow particle size the Industry Leadermodified silicas, cellulose, and NUCLEOSIL is a group of distributionTLC products derived fromtotally porous spherical sili- High separation perform-the list shown below, GFS cancas, featuring very pure, uni- ance due to optimizedalso provide you with thoseform SiO2 structure distrib- bonding propertiesmaterials in a timely manner. High chemical and uted within a small (10 micronmechanical stability and finer), narrow particlePlease refer to the following High load capacity and size range. Their outstandingtables and the alphabetical recovery rates performance in analytical assection for the core GFS prod- High reproducibility from well as preparative columnucts from Macherey-Nagel. lot to lot chromatography stems from 7. All NUCLEOSIL narrow-poreNUCLEODUR describes aAs the name implies, the dura- packings are stable to 8,500new group of spherical silicasbility of this collection of sili- psi; wide bore packings are having average particle sizecas is one of its primary fea- stable to greater than 4,000falling in ranges greater thantures. The new particle size psi. This means there are no10 microns. It takes the placeranges allow for greater sensi- limitations to the HPLC appli-of the NUCLEOPREP group, tivity and versatility in its cations that can benefit from having the advantage of a broad range of applications. the NUCLEOSIL productgreater selection of narrow While the NUCLEOSIL line of group.particle sizes for the 100finer spherical silicas is espe- micron pore size: cially recommended for adsorption chromatography,SPHERICAL SILICASthe NUCLEODUR line is alsoGFS # M-N Code Description well suited to partition chro- (angstrom - micron)IRREGULAR SILICAS matography.CHROMATOGRAPHY2829712000 Nucleosil 50-3 GFS # M-N Code Description2830712010 Nucleosil 50-5(angstrom - micron)2831712020 Nucleosil 50-7 2862711010 Polygosil 60-5GFS# NUCLEODUR2832712030 Nucleosil 50-102863711280 Polygosil 60-72853 713610 Nucleodur 100-102864711020 Polygosil 60-10 2854 713620 Nucleodur 100-162833712360 Nucleosil 100-32865711510 Polygosil 100-5 2855 713600 Nucleodur 100-202834712040 Nucleosil 100-52835712050 Nucleosil 100-72866711520 Polygosil 100-7 2856 713630 Nucleodur 100-302836712060 Nucleosil 100-10 2867711530 Polygosil 100-102857 713551 Nucleodur 100-502837712390 Nucleosil 120-32868711600 Polygosil 300-72838712400 Nucleosil 120-52839712410 Nucleosil 120-72869711890 Polygosil 1000-72840712420 Nucleosil 120-10The new NUCLEODUR C182870711001 Polygoprep 60-12Gravity silica support and col-2841712430 Nucleosil 300-52871711240 Polygoprep 60-20umn packing exhibits excel-2842712440 Nucleosil 300-72872711250 Polygoprep 60-302843712450 Nucleosil 300-10 2873711260 Polygoprep 60-50lent long-term stability and2874711270 Polygoprep 60-80column performance at low2844712680 Nucleosil 500-52875711037 Polygoprep 60-130 and high pH levels. It is espe-2845712690 Nucleosil 500-72846712700 Nucleosil 500-10 2876711002 Polygoprep 100-12 cially well suited for method2877711003 Polygoprep 100-20 development because of its2847712710 Nucleosil 1000-5 2878711540 Polygoprep 100-30 robust character and repro-2848712730 Nucleosil 1000-102879711550 Polygoprep 100-502880711033 Polygoprep 100-80 ducibility in RP-HPLC. Call or2849712850 Nucleosil 4000-5 2881711034 Polygoprep 100-130e-mail for a detailed technical2850712860 Nucleosil 4000-7data sheet; please also inquire2851712870 Nucleosil 4000-102882711004 Polygoprep 300-122883711610 Polygoprep 300-20 regarding the availability of2884711620 Polygoprep 300-30 additional grades of NUCLEO-2885711630 Polygoprep 300-50 DUR having larger pore sizes.2886711035 Polygoprep 1000-122887711036 Polygoprep 1000-202888711005 Polygoprep 1000-302889711006 Polygoprep 1000-50 8. STANDARD SILICASplates and sheets manufac- (60 Angstrom) tured from exactly the same grades (per your choice) of for Low Pressure silica or cellulose. Their range Column Chromatography of ready-to-use layers pro- and Thin Layervides an added measure of Chromatographyversatility to your problem- solving arsenal of resources. TLC LayersMacherey-Nagel silicas can be used immediately as received One of the advantages of no tedious coating or working with Macherey-Nagel impregnation processes are TLC grades of silica (60needed. These TLC plates Angstrom, below), and cellu-have homogeneous, smooth,CHROMATOGRAPHY lose (below) is the assurance well-adhering layers that that you also have prompt ensure reproducible, quantita- access to high quality TLCtive evaluations. Standard silica plates featureGFS #M-N Code Description(CC) silica particles between 5 and2825815380230-400 mesh 17 microns. The thickness of2826815390130-270 mesh the silica layer is 0.25 mm for282781532070-270 meshanalytical plates, and282881533070-230 meshtypically 0.5mm or 1mm thick(TLC) for preparative TLC layers.28198163305-25 micron28208163105-25 micron (GB) Most forms are available with28218163405-25 micron (FI) or without fluorescent indica-28228164105-25 micron (GB, FI) tor; this includes polyester2823816410HP2-25 micronsheets, aluminum sheets, and2824816430HP2-25 micron (GB) glass plates. Additional infor- mation on these and other TLC products is availableCELLULOSE - unmodified powders for TLC from the Macherey-Nagel Chromatography Guide. AllGFS # M-N Code Description these products are available through GFS.2890816250 MN grade 301 (native, fibrous)2891816260 MN grade 301 UV254 (with indicator)2892816270 MN 301 HR (acid washed, de-fatted)2893815050 MN 100 (native, fibrous, purified)2894815060 MN 2100 (high purity grade)2895815070 MN 2100ff (high purity, de-fatted)2896815290 Avicel (microcrystalline) 9. TM HPTLC Layers C-18 SilicaGFSelect Silicas purity, acid washed, irregularsilicas having pore sizes of 40, Reversed Phase Plates for Chromatography 60, 90, and 150 Angstrom In contrast to methodologies Sil...</p>