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PEM response rates falling

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  • Reactions 470 - 25 Sep 1993

    PEM response rates fallingPromotional postmarketing surveillance (PMS)

    studies that are conducted by the pharmaceuticalindustry have had a striking effect on PEM[prescription event monitoring], say ProfessorWilliam Inman and Gillian Pearce from the Drug SafetyResearch Unit (DSRU) in Southampton, UK.

    The response rate to PEM has been falling in recentyears. Data from PEM studies completed since 1984 onthe prescribing patterns of 27 new drugs indicated anoverall response rate of only 53% in terms of useful post-marketing information. Data also indicated thatphysicians who were heavy prescribers of new drugswere less likely to respond to PEM requests for post-marketing information on adverse reactions. Theresponse rate for the heaviest 10% of prescribers was44% and for the heaviest 1% of prescribers was only34%. Non-UK-qualified doctors were more likely to beheavy prescribers of new drugs.

    Prescribers influenced by new drugpromotion

    A more detailed analysis of prescriptions from doctorswho were the heaviest prescribers of new drugsrevealed that prescriptions for 1, and sometimes 2 or 3,new drugs accounted for a high proportion of their totalprescribing (4090% of all their prescriptions). Thisinformation suggests that a minority of prescribersare strongly influenced by promotional techniques,in the opinion of Professor Inman and Pearce. They areconcerned that large numbers of patients are beingexposed to potential risks during the early post-marketing phase of new drugs by expensivepromotional PMS studies conducted by the industry as ameans of increasing sales.Inman W, et al. Prescriber profile and post-marketing surveillance. Lancet 342:658-661, 11 Sep 1993 800222250


    Reactions 25 Sep 1993 No. 4700114-9954/10/0470-0001/$14.95 Adis 2010 Springer International Publishing AG. All rights reserved