Synergy in psychoactive herbs

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<p>Synergy in psychoactive herbs </p> <p>Synergy in psychoactive herbs </p> <p> , , , , , , . -. , , . . . 11 , . , . . (1). </p> <p> . 2 , . , GABA , . , , . , . Hypericum perforatum, Kava Kava, Valeriana </p> <p>3Hypericum perforatum , . , , . (2,3). : naphtodianthrones, flavonoids, phlroglucinols, xanthones, terpenes (1). naphtodianthrone, -xanthones MAO - catechol-o-methyltransferase- COMT (1) , , MAO (1). </p> <p>4, phloroglucinol reuptake , - (4). - (1). (5). , (6). , . , , .</p> <p>5Piper methysticum, Kava KavaKava Kava , . , (1). , : kavain, sihydrokavain, yangonin, dimethyloxyyangonin, methysticin, dihydromethysticin (1). -, (7). GABA . , (1). , reuptake - MAO (1). </p> <p>6 . kavain - dihydromethisticin . -GABA , . . yangonin 20 (1). -kavain (1). </p> <p>7, . , , , , , . , . </p> <p>8Spinella M. The importance of Pharmacological Synergy in Psychoactive Herbal Medicines. Alternative Medicine Review, 2002, 7: 130-137.Kim HL. Strelzer J. Goebert D. St. John's wort for depression: a meta analysis of well-defined clinical trials. J. Nerv. Ment Dis 1999, 187: 532-538.Linde K. Ramirez G. Mulrow CD. et al. St. John's wort for depression- an overeview and meta-analysis of randomized clinical trials. BNJ 1996, 313: 253-258.Muller WE. Singer A. Wonnemann M. et al. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiatry 1998, 31: 16-21.Chatterjee SS. Noldner M. Koch M. et al. Antidepressant activity of Hypericum perforatum and Hyperforin: the neglected possibility. Pharmacopsychiatry 1997, 30:117-124.Bennett DA. Phun L. Polk JF. et al. Neuropharmacology of St. John's wort (Hypericum). Ann Pharmacother. 1998, 32: 1201-1208.Keledjian J. Duffield PH. Jamieson DD. et al. Uptake into mouse brain of four compounds present in psychoactive beverage kava. J. Pharm. Sci. 1988, 77: 1003-1006.</p> <p>9 </p> <p> 484 , . Hypericum perforatum . . , , , , , . : naphthodianthrones , phloroglucinol : , , , </p> <p>10 , (1). . , . Hypericum richeri . 3 (1). naphthdianthrones :Hypericum hisspifolium Hypericum triquetrifolium- </p> <p>11 acylphloroglucinol Hypericum scabrum . , . . , .Stajavnic G. Dordevic A. Smelcerovic A. Do other Hypericum species have medicinal potential as St. John'd wort? Curr. Med. Chem. 2013 20: 2273-2295.12</p>