System Biology Team Project Chemicals- Tryptophan 組員: 林瑋耿, 吳東耘, 許博凱, 彭嘉冠

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  • System Biology Team Project Chemicals- Tryptophan , , ,
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  • System Biology Tryptophan Molecular formula C 11 H 12 N 2 O 2 Molecular weight 204.23 Isoelectric point pH 5.89 CAS number 73-22-3 Functional group : indole
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  • System Biology Where to get it ? Tryptophan was available in health food Banana, milk, fish, and etc.
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  • System Biology What are its usage ? Tryptophan is effective sleep aid. It shows considerable promise as an antidepressant. Other promising indications include reduce some emotional disorders. Impulsive, violent, and etc. disorders
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  • System Biology Cont. ( ) serotonin , , melatonin , , , , Serotonin melatonin , B3 ( , niacin) , (coenzyme) IAA (auxin)
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  • System Biology
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  • NAD + & NADH 2e - + 2H +
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  • System Biology Tryptophan Biosynthesis
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  • System Biology Inhibited by L-tyrosine Inhibited by L-tryptophan Inhibited by L-phenyalanine 1 2 5 3 4 6 7 1 - Phospho-2-dehydro-3-deoxyheptonate aldolase [EC:2.5.1.54]2.5.1.54 2- 3-dehydroquinate synthase [EC:4.2.3.4]4.2.3.4 3- 3-dehydroquinate dehydratase (3-dehydroquinase) [EC:4.2.1.10]4.2.1.10 Enolase [EC:4.2.1.11]4.2.1.11 4- shikimate 5-dehydrogenase [EC:1.1.1.25]1.1.1.25 5- shikimate kinase II (SKII) [EC:2.7.1.71]2.7.1.71 6- 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]2.5.1.19 7- chorismate synthase [EC:4.2.3.5]4.2.3.5
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  • System Biology Inhibited by L-tryptophan 8 & 9- anthranilate phosphoribosyltransferase / anthranilate synthase component II [EC:2.4.2.18, 4.1.3.27]2.4.2.184.1.3.27 10 & 11- indole-3-glycerol phosphate synthase (IGPS) / N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI) [EC:4.1.1.48, 5.3.1.24]4.1.1.485.3.1.24 12- tryptophan synthase [EC:4.2.1.20]4.2.1.20 8 9 11 10 12
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  • System Biology
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  • Tryptophan operon in E.coli trpD + trpE = enzyme 8 & 9 trpC = enzyme 10 & 11 trpA + trpB = enzyme 12 Control the 5 reactions from chorismate to tryptophan !!
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  • System Biology Trp operon mechanism
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  • System Biology References KEGG: http://www.genome.jp/kegg/http://www.genome.jp/kegg/ EcoCyc: http://www.ecocyc.com/http://www.ecocyc.com/ free encyclopedia: http://en.wikipedia.org/wiki/Main_Page http://en.wikipedia.org/wiki/Main_Page
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  • System Biology The End