System Biology Team Project Chemicals- Tryptophan 組員: 林瑋耿, 吳東耘, 許博凱, 彭嘉冠

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<ul><li> Slide 1 </li> <li> System Biology Team Project Chemicals- Tryptophan , , , </li> <li> Slide 2 </li> <li> System Biology Tryptophan Molecular formula C 11 H 12 N 2 O 2 Molecular weight 204.23 Isoelectric point pH 5.89 CAS number 73-22-3 Functional group : indole </li> <li> Slide 3 </li> <li> System Biology Where to get it ? Tryptophan was available in health food Banana, milk, fish, and etc. </li> <li> Slide 4 </li> <li> System Biology What are its usage ? Tryptophan is effective sleep aid. It shows considerable promise as an antidepressant. Other promising indications include reduce some emotional disorders. Impulsive, violent, and etc. disorders </li> <li> Slide 5 </li> <li> System Biology Cont. ( ) serotonin , , melatonin , , , , Serotonin melatonin , B3 ( , niacin) , (coenzyme) IAA (auxin) </li> <li> Slide 6 </li> <li> System Biology </li> <li> Slide 7 </li> <li> Slide 8 </li> <li> NAD + &amp; NADH 2e - + 2H + </li> <li> Slide 9 </li> <li> System Biology Tryptophan Biosynthesis </li> <li> Slide 10 </li> <li> System Biology Inhibited by L-tyrosine Inhibited by L-tryptophan Inhibited by L-phenyalanine 1 2 5 3 4 6 7 1 - Phospho-2-dehydro-3-deoxyheptonate aldolase [EC:2.5.1.54]2.5.1.54 2- 3-dehydroquinate synthase [EC:4.2.3.4]4.2.3.4 3- 3-dehydroquinate dehydratase (3-dehydroquinase) [EC:4.2.1.10]4.2.1.10 Enolase [EC:4.2.1.11]4.2.1.11 4- shikimate 5-dehydrogenase [EC:1.1.1.25]1.1.1.25 5- shikimate kinase II (SKII) [EC:2.7.1.71]2.7.1.71 6- 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]2.5.1.19 7- chorismate synthase [EC:4.2.3.5]4.2.3.5 </li> <li> Slide 11 </li> <li> System Biology Inhibited by L-tryptophan 8 &amp; 9- anthranilate phosphoribosyltransferase / anthranilate synthase component II [EC:2.4.2.18, 4.1.3.27]2.4.2.184.1.3.27 10 &amp; 11- indole-3-glycerol phosphate synthase (IGPS) / N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI) [EC:4.1.1.48, 5.3.1.24]4.1.1.485.3.1.24 12- tryptophan synthase [EC:4.2.1.20]4.2.1.20 8 9 11 10 12 </li> <li> Slide 12 </li> <li> System Biology </li> <li> Slide 13 </li> <li> Tryptophan operon in E.coli trpD + trpE = enzyme 8 &amp; 9 trpC = enzyme 10 &amp; 11 trpA + trpB = enzyme 12 Control the 5 reactions from chorismate to tryptophan !! </li> <li> Slide 14 </li> <li> System Biology Trp operon mechanism </li> <li> Slide 15 </li> <li> System Biology References KEGG: http://www.genome.jp/kegg/http://www.genome.jp/kegg/ EcoCyc: http://www.ecocyc.com/http://www.ecocyc.com/ free encyclopedia: http://en.wikipedia.org/wiki/Main_Page http://en.wikipedia.org/wiki/Main_Page </li> <li> Slide 16 </li> <li> System Biology The End </li> </ul>