Team Project Chemicals- Tryptophan

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    12-Jan-2016

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Team Project Chemicals- Tryptophan. , , , . Tryptophan. Molecular formula C 11 H 12 N 2 O 2 Molecular weight 204.23 Isoelectric point pH 5.89 CAS number 73-22-3. Functional group : indole. Where to get it ?. Tryptophan was available in health food - PowerPoint PPT Presentation

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  • Team ProjectChemicals- Tryptophan, , ,

  • TryptophanMolecular formulaC11H12N2O2Molecular weight204.23Isoelectric pointpH 5.89CAS number73-22-3Functional group : indole

  • Where to get it ?Tryptophan was available in health foodBanana, milk, fish, and etc.

  • What are its usage ?Tryptophan is effective sleep aid.It shows considerable promise as an antidepressant.Other promising indications include reduce some emotional disorders.Impulsive, violent, and etc. disorders

  • Cont. ()serotonin, , melatonin, , , , Serotoninmelatonin, B3 (, niacin) , (coenzyme) IAA (auxin)

  • NAD+ & NADH2e- + 2H+

  • Tryptophan Biosynthesis

  • Inhibited by L-tyrosineInhibited by L-tryptophanInhibited byL-phenyalanine12534671- Phospho-2-dehydro-3-deoxyheptonate aldolase [EC:2.5.1.54]2- 3-dehydroquinate synthase [EC:4.2.3.4]3- 3-dehydroquinate dehydratase (3-dehydroquinase) [EC:4.2.1.10] Enolase [EC:4.2.1.11]4- shikimate 5-dehydrogenase [EC:1.1.1.25]5- shikimate kinase II (SKII) [EC:2.7.1.71]6- 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]7- chorismate synthase [EC:4.2.3.5]

  • Inhibited by L-tryptophan8 & 9- anthranilate phosphoribosyltransferase / anthranilate synthase component II [EC:2.4.2.18, 4.1.3.27]10 & 11- indole-3-glycerol phosphate synthase (IGPS) / N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI) [EC:4.1.1.48, 5.3.1.24]12- tryptophan synthase [EC:4.2.1.20]89111012

  • Tryptophan operon in E.colitrpD + trpE = enzyme 8 & 9trpC = enzyme 10 & 11trpA + trpB = enzyme 12Control the 5 reactions from chorismate to tryptophan !!

  • Trp operon mechanism

  • ReferencesKEGG: http://www.genome.jp/kegg/EcoCyc: http://www.ecocyc.com/free encyclopedia: http://en.wikipedia.org/wiki/Main_Page

  • The End

    Blood-brain barrier