Синаптична передача збудження: базові відомості та генетичний аспект

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1. ..., . .. " " blacknick@blacknick.info 2. 3. : (. -, ) . , 1897 . 10^15 1 000 000 000 000 000 4. 5. - - - 6. . , . , , . , , , , 7. "" "" 8. B C - 9. - 10. , , , , 11. 12. , . : 13. () ( ) () - () (D) 14. , , 15. , , , : nK:nNa:nCl = 1:0.04:0.45 16. : 17. 18. , 19. , 20. 21. 22. : : 23. - () 24. : - - (Ca2+ ) 25. 26. - - () 27. 28. , 29. : - , ( ) , 30. : ( ) G- G- (, ) , ( ) 31. , / , 32. , , , Na, K, Cl () () , ? 33. (Cl- ) (K+ ) (Na+ ) 34. , : ( ) 35. () () 36. , , - - 37. : , : > , > , > 38. : - (, ) , - 39. : (3-4 ) , (20-40 ) () (1-5 ) (), 40. () - () () 41. : () 42. NMDA- - 77 49 ' 43. : ( ) ( ) ( ) 44. 45. : - REM- 46. 47. , 48. 49. (reuptake) ; , ! , 50. ; , , 51. () () . 52. , . 53. , . . , . 54. Myotonia congenita , CLCN1 , ? 55. Myotonia congenita 56. Tackling the synaptopathy challenges - synaptic systems biology from molecules to networks 57. 58. C57BL/A Inbr(A)?+142. Origin. Little to A c1932. Maint. by A. C57BL/An Little to Andervont 1932. Differs from B6 and B10 at the Ce1 locus. C57BL/GrFa. Origin: Little to Gruneberg 1932, to Falconer 1947. Most British substrains derived from this stock, though 6 and 10 substrains have been imported more recently. This substrain seems to resemble the 6 rather than the 10 substrain. C57BL/KaLwN. To N 1965 from Lw at F35. C57BL/Ks C57BL/6 Inbr (J) 150. Origin: substrains 6 and 10 were separated prior to 1937. This substrain is now probably the most widely used of all inbred strains. Substrain 6 and 10 differ at the H9, Igh2 and Lv loci. Maint. by J,N, Ola. C57BL/10 Inbr (J) 158. Origin: see C57BL/6. C57BL/10ScSn. Inbr (J)? +136. Little to W.L.Russell to J.P.Scott at F26 as a separate substrain. To Snell at F35-36. Behaviour differs from C57BL/10J. C57BL/10Cr Carries spontaneous lipopolysaccharide mutation lps which appears to resemble that found in C3H/HeJ. C57BL/Ola Carries a spontaneous mutation, Wlds, causing a marked slowing of axonal degeneration during Wallerian degeneration C57BL/6 59. , , , , , . 1. 2. 3. 4. 60. 2000 , 1500 . / 200 130 . 200 ' 133 . 61. , 62. (R), (S) (E). 63. , . , ' , . 64. : (). 65. '!